(2-Chloro-5-pyridyl)methylzinc chloride
(2-Chloro-5-pyridyl)methylzinc chloride
CAS: 352530-36-0
Molecular Formula: C6H5Cl2NZn
(2-Chloro-5-pyridyl)methylzinc chloride - Names and Identifiers
(2-Chloro-5-pyridyl)methylzinc chloride - Physico-chemical Properties
| Molecular Formula | C6H5Cl2NZn |
| Molar Mass | 227.41 |
| Density | 0.992g/mLat 25°C |
| Boling Point | 65°C |
| Flash Point | 1°F |
| Storage Condition | 2-8°C |
(2-Chloro-5-pyridyl)methylzinc chloride - Risk and Safety
| Risk Codes | R11 - Highly Flammable R19 - May form explosive peroxides R36/37 - Irritating to eyes and respiratory system. R40 - Limited evidence of a carcinogenic effect |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S33 - Take precautionary measures against static discharges. S36/37 - Wear suitable protective clothing and gloves. |
| UN IDs | UN 2056 3/PG 2 |
| WGK Germany | 1 |
(2-Chloro-5-pyridyl)methylzinc chloride - Introduction
(2-Chloro-5-pyridyl)methylzinc chloride is an organic compound with the chemical formula C6H6Cl2N2Zn. It is a white solid, soluble in organic solvents such as cyclohexane and toluene.
(2-Chloro-5-pyridyl)methylzinc chloride can be used for catalyst synthesis, reduction reaction in organic synthesis and preparation of artificial synthetic enzymes. It can be used as an active reagent in organic synthesis reactions, for example as a nucleophile in reaction with halogenated hydrocarbons to form bonded carbon atoms. In addition, it can also be used in the field of materials science.
The method for preparing (2-Chloro-5-pyriridyl) methylzinc chloride mainly uses (2-chloro-5-pyridyl) methyl lithium and zinc chloride as raw materials. First, zinc chloride was dissolved in dry dimethylformamide, then (2-chloro-5-pyridyl) methyllithium was slowly added dropwise, and the reaction mixture was heated. After completion of the reaction, the product can be obtained by concentration and crystallization.
When using and handling (2-Chloro-5-pyridyl)methylzinc chloride, it is necessary to note that the vapor of its organic solvent may be toxic. Therefore, work in a well-ventilated area and wear personal protective equipment such as protective gloves and goggles. At the same time, avoid contact with skin, eyes and clothing. In addition, waste such as zinc chloride should be disposed of in accordance with relevant regulations.
(2-Chloro-5-pyridyl)methylzinc chloride can be used for catalyst synthesis, reduction reaction in organic synthesis and preparation of artificial synthetic enzymes. It can be used as an active reagent in organic synthesis reactions, for example as a nucleophile in reaction with halogenated hydrocarbons to form bonded carbon atoms. In addition, it can also be used in the field of materials science.
The method for preparing (2-Chloro-5-pyriridyl) methylzinc chloride mainly uses (2-chloro-5-pyridyl) methyl lithium and zinc chloride as raw materials. First, zinc chloride was dissolved in dry dimethylformamide, then (2-chloro-5-pyridyl) methyllithium was slowly added dropwise, and the reaction mixture was heated. After completion of the reaction, the product can be obtained by concentration and crystallization.
When using and handling (2-Chloro-5-pyridyl)methylzinc chloride, it is necessary to note that the vapor of its organic solvent may be toxic. Therefore, work in a well-ventilated area and wear personal protective equipment such as protective gloves and goggles. At the same time, avoid contact with skin, eyes and clothing. In addition, waste such as zinc chloride should be disposed of in accordance with relevant regulations.
Last Update：2024-04-10 22:29:15
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