(2-Methoxypyrimidin-5-yl)boronic acid

(2-Methoxypyrimidin-5-yl)boronic acid - Names and Identifiers

Name	2-Methoxypyrimidine-5-boronic acid
Synonyms	2-METHOXYL-5-PYRIMIDYLBORIC ACID 2-Methoxy-5-Pyrimidineboronic Acid 2-Methoxypyrimidine-5-boronic acid 2-METHOXYPYRIMIDINE-5-BORONIC ACID 2-METHOXY-5-PYRIMIDINEBORONIC ACID 2-METHOXYPYRIMIDIN-5-YLBORONIC ACID (2-Methoxypyrimidin-5-yl)boronic acid (2-Methoxy-5-pyrimidinyl)boronic acid 2-methoxypyrimidin-5-yl-5-boronic acid Boronic acid, B-(2-methoxy-5-pyrimidinyl)- 5-Borono-2-methyoxypyrimidine, 5-Borono-2-methoxy-1,3-diazine 2-Methoxy-5-pyriMidylboronic Acid (contains varying aMounts of Anhydride)
CAS	628692-15-9
EINECS	670-240-4
InChI	InChI=1/C5H7BN2O3/c1-11-5-7-2-4(3-8-5)6(9)10/h2-3,9-10H,1H3
InChIKey	YPWAJLGHACDYQS-UHFFFAOYSA-N

(2-Methoxypyrimidin-5-yl)boronic acid - Physico-chemical Properties

Molecular Formula	C5H7BN2O3
Molar Mass	153.93
Density	1.33±0.1 g/cm3(Predicted)
Melting Point	161°C(lit.)
Boling Point	378.3±52.0 °C(Predicted)
Flash Point	182.593°C
Solubility	soluble in Methanol
Vapor Presure	0mmHg at 25°C
Appearance	powder to crystal
Color	White to Light yellow
pKa	5.59±0.11(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Refractive Index	1.523

(2-Methoxypyrimidin-5-yl)boronic acid - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	R36 - Irritating to the eyes R41 - Risk of serious damage to eyes R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
HS Code	29349990
Hazard Class	IRRITANT

(2-Methoxypyrimidin-5-yl)boronic acid - Introduction

Acid is an organic compound with the chemical formula C5H7BN2O3. It is a white crystalline powder, soluble in water and some organic solvents. The following is a description of its nature, use, preparation and safety information:

Nature:
-Chemical properties: acid is a boronic acid compound containing a pyrimidine ring and a methoxy group. It has good stability and chemical inertness.
-Appearance: White crystal powder
-Solubility: Soluble in water and some organic solvents
-storage conditions: should be stored in a dry, ventilated place, away from fire and oxidant.

Use:
Cr acid has important application value. It is often used as a boric acid esterification reagent in organic synthesis to catalyze cross-coupling reactions, such as Suzuki reaction and Stille reaction. It can react with a compound containing an active halogen to form the corresponding boronic ester or ketone.

Preparation Method:
There are many ways to prepare acid, and common methods include:
-Pyrimidine and boric acid reaction: pyrimidine and boric acid are reacted in an appropriate solvent, and the reaction is heated to obtain the target product.
-2-Methoxy ypyrimidine and triphenylboron reaction: Under appropriate solvent and conditions, 2-methoxy ypyrimidine and triphenylboron are reacted, and then acid hydrolysis is carried out to obtain fluoryl acid.
-Other methods: It can also be synthesized by other methods, such as metal catalyzed reaction, reduction reaction, etc.

Safety Information:
Acid is generally safer under normal conditions of use. However, as a chemical, it still has some safety concerns:
-Flammability: acid is a combustible and should be kept away from open flames and high temperatures.
-Corrosive: acid may be irritating to the skin and eyes. Rinse with plenty of water immediately after contact. Personal protective equipment such as protective gloves and goggles should be worn during operation.
-Toxicity: The toxicity of acid is still low, but intake and inhalation should be avoided. If ingested or inhaled, seek medical help immediately.

Last Update：2024-04-10 22:29:15