(25R)-2α,3β-Dihydroxy-5α-spirostan
Gitogenin
CAS: 511-96-6
Molecular Formula: C27H44O4
(25R)-2α,3β-Dihydroxy-5α-spirostan - Names and Identifiers
(25R)-2α,3β-Dihydroxy-5α-spirostan - Physico-chemical Properties
| Molecular Formula | C27H44O4 |
| Molar Mass | 432.64 |
| Density | 1.16 |
| Melting Point | 272-273℃ |
| Boling Point | 466.26°C (rough estimate) |
| Specific Rotation(α) | D20 -75° (c = 1.02 in CHCl3) |
| Solubility | Soluble in methanol, ethanol, DMSO and other organic solvents |
| Appearance | Powder |
| pKa | 14.62±0.70(Predicted) |
| Storage Condition | 2-8℃ |
| Refractive Index | 1.4840 (estimate) |
| MDL | MFCD00273328 |
| Physical and Chemical Properties | Powder, soluble in methanol, ethanol, DMSO and other organic solvents, from Ophiopogon japonicus, Fama, Huluba, Tribulus terrestris root, big fish swim bladder flower. |
| In vitro study | When tamoxifen is used as the substrate metabolized by UGT1A4 in HLMs, Gitogenin exhibits potent inhibition of tamoxifen, with an IC 50 value of 6.13 µM. Similarly, for midazolam as the substrate of UGT1A4, the IC 50 value is 5.7 µM. In addition, when olanzapine is used as a substrate of UGT1A4, the IC 50 value is determined as 6.0 µM. Finally, we also evaluats Gitogenin for asenapine glucuronidation mediated by UGT1A4, and similar inhibition effect is observed, with an IC 50 value of 22.0 µM. |
| In vivo study | Stimulation of growth hormone release is investigated on rat pituitary cells in vitro. Gitogenin (20 μg/mL) shows rat growth-hormone (rGH) release stimulating activities (26.1 ng/mL). |
(25R)-2α,3β-Dihydroxy-5α-spirostan - Reference Information
| Overview | desapogenin is one of the chemical constituents of the flower of Amur. Experimental study on the chemical constituents of the flower of the flower, the quality control of the flower, the clinical rational drug use and further development and utilization of Mongolian medicine to provide a scientific basis. The use of solvent extraction and extraction division, the use of tube plate method to study the antibacterial activity of each part of the common strains, screening active sites, the use of solvent method and a variety of modern chromatographic techniques (silica gel, SephadexLH-20, RP-18, HP-20 macroporous adsorption resin column chromatography) on the extraction parts of the flower of the system separation, using physical and chemical identification and modern spectral analysis techniques (MS, 1H-NMR, 13C-NMR, DEPT and 1h-1hcos, HSQC, HMBC, etc. 2D NMR) identify the structure of the compound. |
| biological activity | Gitogenin is a natural steroid isolated from the whole plant of Tribulus longipetalus, they are selective inhibitors of UDP-glucuronyltransferase 1A4 (UGT1A4) and α-glucosidase with IC50 values of 0.69 µm (using trifluoperazine as substrate). And 37.2 μm, and does not inhibit the activity of the major human cytochrome P450 subtype. |
| Target | IC50: 0.69 µm (UDP-glucuronosyltransferase 1A4); IC50: 37.2 μm (α-glucosidase) |
| Usage | aposanin has the function of improving blood circulation and treating cerebral ischemia. |
Last Update：2024-04-09 20:02:46
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Mobile: 18021002903
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Wechat: 18301782025
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