Name | Pennogenin |
Synonyms | Pennogenin PENNOGENIN (25R)-Spirost-5-ene-3β,17-diol (3β,25R)-Spirost-5-en-3,17-diol (3beta,25R)-spirost-5-en-3,17-diol Spirost-5-ene-3,17-diol, (3β,25R)- |
CAS | 507-89-1 |
Molecular Formula | C27H42O4 |
Molar Mass | 430.62 |
Density | 1.18±0.1 g/cm3(Predicted) |
Melting Point | 247 °C |
Boling Point | 565.0±50.0 °C(Predicted) |
Appearance | Powder |
pKa | 14.02±0.70(Predicted) |
Storage Condition | 2-8℃ |
In vitro study | Pennogenin exhibits significant level of oxidative burst suppressive activity. Pennogenin exhibits significant in vitro inhibitory effect on release of ROS from whole blood, with an IC 50 of 5.0 µg/mL. |
Overview | Pennogenin with 17-hydroxysteroid Spiro structure the glycoside compound is one of the active ingredients of the medicinal plant, Paris. Spout brain Saponins are mainly found in the Paridis plants of yanlingcao family, a total of 24 species in the world, 19 species in China, mainly in the southwest, one of the more common is a flower (Paris polyphylla asmith). Many kinds of rhizomes in this genus can be used for medicinal purposes, with hemostatic, expectorant, antibacterial, analgesic and other effects, for functional uterine bleeding, snake bites, bruises, the treatment of unknown swelling and pain has become the main raw material of many Chinese patent medicines and new drugs. Due to the annual consumption of far beyond the annual growth of Paridis, long-term excavation of wild plants not only exacerbates the lack of plant resources of a variety of famous traditional Chinese medicine, but also inevitably leads to the destruction of vegetation, affecting the ecological environment. |
Use | the meta-sapogenin is a natural product of bégen, a small steroid component of bégen. Traditional Chinese Medicine "Paridis" also have. |
biological activity | Pennogenin is a natural product that can be extracted from the rhizomes of Tibetan Trillium. Pennogenin significantly inhibited the release of reactive oxygen species (ROS) in vitro. |