(3-fluoro-5-methoxycarbonyl-phenyl)boronic acid

(3-fluoro-5-methoxycarbonyl-phenyl)boronic acid - Names and Identifiers

Name	(3-fluoro-5-methoxycarbonyl-phenyl)boronic acid
Synonyms	METHYL 3-BORONO-5-FLUOROBENZOATE (3-FLUORO-5-METHOXYCARBONYLPHENYL)BORONIC ACID (3-fluoro-5-methoxycarbonyl-phenyl)boronic acid (3-FLUORO-5-METHOXYCARBONYL)BENZENEBORONIC ACID (3-Fluoro-5-(Methoxycarbonyl)Phenyl)Boronic Acid
CAS	871329-62-3
InChI	InChI=1/C8H8BFO4/c1-14-8(11)5-2-6(9(12)13)4-7(10)3-5/h2-4,12-13H,1H3

(3-fluoro-5-methoxycarbonyl-phenyl)boronic acid - Physico-chemical Properties

Molecular Formula	C8H8BFO4
Molar Mass	197.96
Density	1.33g/cm³
Melting Point	138-142
Boling Point	372.5°C at 760 mmHg
Flash Point	179.1°C
Water Solubility	Slightly soluble in water.
Vapor Presure	3.3E-06mmHg at 25°C
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.513

(3-fluoro-5-methoxycarbonyl-phenyl)boronic acid - Risk and Safety

Risk Codes	22 - Harmful if swallowed
Hazard Note	Irritant

(3-fluoro-5-methoxycarbonyl-phenyl)boronic acid - Introduction

boronic acid is an important intermediate compound in organic synthesis, the chemical formula is C9H9BFNO4. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: White solid.
-Melting point: about 140-143°C.
-Solubility: Soluble in some organic solvents, such as dichloromethane and ethanol.

Use:
- (Bi) boronic acid is an important aryl boronic acid derivative, which is widely used as a substituent in organic synthesis, and participates in a variety of important reactions, such as zuki coupling reaction, Negishi coupling reaction and Stille coupling reaction.
-It can be used to synthesize various organic compounds containing aromatic groups, such as drugs, pesticides, dyes and cosmetic raw materials.

Preparation Method:
(Br) boronic acid can be prepared by the following methods:
1. 3-fluoro-5-methoxycarbonylphenylboronic acid is synthesized by reacting 3-fluorophenylboronic acid with methoxycarbonyl thionyl chloride.
2. the reaction of phenyl trifluoroborane and methoxy carbonyl thionyl chloride, and then deoxygenated to generate the target product.

Safety Information:
- (a) boronic acid has limited toxicity information, but it is generally considered to have the potential toxicity of general organic compounds.
-During operation, routine laboratory safety measures should be followed.
-When in contact with skin, rinse immediately with soap and water.
-Avoid inhaling the gas of its dust or solution.
-During use, avoid contact with strong oxidants and strong acids.

Please note that this is only a brief description of the compound. For in-depth understanding and use of the compound, please consult a professional and refer to relevant literature.

Last Update：2024-04-09 15:18:00