(3R)-3-(dimethylamino)-1-pyrrolidinecarboxylic acid tert-butyl ester
1-Pyrrolidinecarboxylicacid, 3-(dimethylamino)-, 1,1-dimethylethyl ester, (3R)-
CAS: 1004538-33-3
Molecular Formula: C11H22N2O2
(3R)-3-(dimethylamino)-1-pyrrolidinecarboxylic acid tert-butyl ester - Names and Identifiers
(3R)-3-(dimethylamino)-1-pyrrolidinecarboxylic acid tert-butyl ester - Physico-chemical Properties
| Molecular Formula | C11H22N2O2 |
| Molar Mass | 214.3 |
| Storage Condition | 2-8°C |
(3R)-3-(dimethylamino)-1-pyrrolidinecarboxylic acid tert-butyl ester - Introduction
R-1-Boc-3-(dimethylamino) pyrrolidine, also known as Boc-DMPA, is an organic compound. Its nature is as follows:
1. appearance: usually white or similar to white solid.
2. molecular formula: C11H21N3O2.
3. Molecular weight: 227.3g/mol.
4. solubility: soluble in common organic solvents, such as dimethyl sulfoxide and dichloromethane.
R-1-Boc-3-(dimethylamino) pyrrolidine is mainly used for protecting group reactions in organic synthesis. Boc is a protecting group capable of protecting the reactivity of the amine group from undesired side reactions in the reaction. In addition, it can also be used to synthesize some intermediate compounds in the field of medicine.
The method for preparing R-1-Boc-3-(dimethylamino) pyrrolidine is as follows:
1. First, pyrrolidine is reacted with a dimethylamino compound through an o-amino group to obtain 3-(dimethylamino) pyrrolidine.
2. Next, the obtained 3-(dimethylamino) pyrrolidine is reacted with Boc anhydride to produce R-1-Boc-3-(dimethylamino) pyrrolidine.
When using R-1-Boc-3-(dimethylamino) pyrrolidine, there are some safety precautions, including the following:
1. need to operate in well ventilated laboratory conditions.
2. Avoid contact with skin and eyes to prevent irritation and damage.
3. Use appropriate personal protective equipment, such as lab gloves and goggles.
4. storage should be sealed, avoid direct sunlight.
5. In the use and handling of the compound, should follow the laboratory safety procedures.
1. appearance: usually white or similar to white solid.
2. molecular formula: C11H21N3O2.
3. Molecular weight: 227.3g/mol.
4. solubility: soluble in common organic solvents, such as dimethyl sulfoxide and dichloromethane.
R-1-Boc-3-(dimethylamino) pyrrolidine is mainly used for protecting group reactions in organic synthesis. Boc is a protecting group capable of protecting the reactivity of the amine group from undesired side reactions in the reaction. In addition, it can also be used to synthesize some intermediate compounds in the field of medicine.
The method for preparing R-1-Boc-3-(dimethylamino) pyrrolidine is as follows:
1. First, pyrrolidine is reacted with a dimethylamino compound through an o-amino group to obtain 3-(dimethylamino) pyrrolidine.
2. Next, the obtained 3-(dimethylamino) pyrrolidine is reacted with Boc anhydride to produce R-1-Boc-3-(dimethylamino) pyrrolidine.
When using R-1-Boc-3-(dimethylamino) pyrrolidine, there are some safety precautions, including the following:
1. need to operate in well ventilated laboratory conditions.
2. Avoid contact with skin and eyes to prevent irritation and damage.
3. Use appropriate personal protective equipment, such as lab gloves and goggles.
4. storage should be sealed, avoid direct sunlight.
5. In the use and handling of the compound, should follow the laboratory safety procedures.
Last Update：2024-04-09 21:01:54
