(3R,4S)-3-(FMOC-AMINO)-4-METHYLHEXANOIC ACID
Fmoc-L-beta-homoisoleucine
CAS: 193954-27-7
Molecular Formula: C22H25NO4
(3R,4S)-3-(FMOC-AMINO)-4-METHYLHEXANOIC ACID - Names and Identifiers
| Name | Fmoc-L-beta-homoisoleucine |
| Synonyms | Fmoc-β-HoIle-OH FMOC-Β-HOMOILE-OH FMOC-BETA-HOILE-OH FMOC-ILE-(C*CH2)OH FMOC-BETA-HOMOILE-OH Fmoc-β-homoisoleucine Fmoc-L-β-homoisoleucine Fmoc-L-beta-homoisoleucine FMOC-L-BETA-HOMOISOLEUCINE (3R,4S)-3-(FMOC-AMINO)-4-METHYLHEXANOIC ACID N-BETA-(9-FLUORENYLMETHOXYCARBONYL)-BETA-HOMOISOLEUCINE (R)-N-B-(9-FLUORENYLMETHOXYCARBONYL)-3-AMINO-METHYLHEXANOIC ACID (3R,4S)-3-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-4-METHYL-HEXANOIC ACID (3R,4S)-3-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-4-methylhexanoic acid (3R,4R)-3-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-4-methylhexanoic acid |
| CAS | 193954-27-7 |
| InChI | InChI=1/C22H25NO4/c1-3-14(2)20(12-21(24)25)23-22(26)27-13-19-17-10-6-4-8-15(17)16-9-5-7-11-18(16)19/h4-11,14,19-20H,3,12-13H2,1-2H3,(H,23,26)(H,24,25)/t14-,20+/m0/s1 |
| InChIKey | VHZUUIWBAYOCDD-JLTOFOAXSA-N |
(3R,4S)-3-(FMOC-AMINO)-4-METHYLHEXANOIC ACID - Physico-chemical Properties
| Molecular Formula | C22H25NO4 |
| Molar Mass | 367.44 |
| Density | 1.188±0.06 g/cm3(Predicted) |
| Melting Point | 98-100 °C(Solv: hexane (110-54-3); ethyl acetate (141-78-6)) |
| Boling Point | 572.1±33.0 °C(Predicted) |
| Flash Point | 299.8°C |
| Vapor Presure | 6.3E-14mmHg at 25°C |
| BRN | 7980987 |
| pKa | 4.41±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.576 |
| Physical and Chemical Properties | Storage Conditions: 2-8 ℃ WGK Germany:3 |
(3R,4S)-3-(FMOC-AMINO)-4-METHYLHEXANOIC ACID - Risk and Safety
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
(3R,4S)-3-(FMOC-AMINO)-4-METHYLHEXANOIC ACID - Introduction
Nature:
Fmoc-L-beta-homoisoleucine is a white crystalline solid with a molecular weight of 400.5g/mol. It is stable at ambient temperature and soluble in organic solvents such as dimethyl-glaciol and methylene chloride.
Use:
Fmoc-L-beta-homoisoleucine is one of the commonly used building blocks in the synthesis of peptides and proteins. It is usually introduced into the polypeptide chain as a hetero amino acid and can be used to alter the properties and functions of the polypeptide molecule. Because of its large spatial structure and special side chain properties, Fmoc-L-beta-homoisoleucine can be used to design polypeptide drugs with special biological activity and stability.
Method:
Fmoc-L-beta-homoisoleucine are usually made by chemical synthesis. Detailed synthetic steps include the introduction of protecting groups, the synthesis of reactive derivatives and the final deprotection reaction. The entire synthesis process needs to be carried out in an organic synthesis laboratory, and the reaction conditions need to be strictly controlled to ensure the purity and yield of the product.
Safety Information:
Fmoc-L-beta-homoisoleucine is relatively safe to use under normal laboratory conditions. However, as laboratory reagents, appropriate safety measures still need to be taken. Wear suitable protective equipment to avoid inhalation and contact. In addition, it should be operated under well-ventilated conditions and follow relevant safe operating procedures. If inhaled or exposed, wash the affected area immediately and seek medical help if necessary.
Last Update：2024-04-09 20:52:54
