(3aS,4S,6S,7aR)-Hexahydro-3a,5,5-trimethyl-alpha-(phenylmeth...
(3aS,4S,6S,7aR)-Hexahydro-3a,5,5-trimethyl-alpha-(phenylmethyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine trifluoroacetate
CAS: 514820-49-6
Molecular Formula: C20H27BF3NO4
(3aS,4S,6S,7aR)-Hexahydro-3a,5,5-trimethyl-alpha-(phenylmeth... - Names and Identifiers
(3aS,4S,6S,7aR)-Hexahydro-3a,5,5-trimethyl-alpha-(phenylmeth... - Physico-chemical Properties
| Molecular Formula | C20H27BF3NO4 |
| Molar Mass | 413.24 |
(3aS,4S,6S,7aR)-Hexahydro-3a,5,5-trimethyl-alpha-(phenylmeth... - Introduction
(3aS,4S,6S,7aR)-Hexahydro-3a,5,5-trimethyl-alpha-(phenylmethyl)-4,6-methano-1,3, trifluoroacetate, abbreviated as TRMB, is an organic compound. The following is a description of the nature, use, method and safety information of the TMB:
Nature:
TRMB is a solid with a chemical formula of C18H24BF3NO2 and a relative molecular mass of 355.20g/mol. Its structure contains benzene and thiophene rings, as well as methylamine and trifluoroacetate ions.
Use:
TRMB is an important intermediate in organic synthesis. It can be used as a starting material for the synthesis of new drug molecules in medicinal chemistry. In addition, TRMB can also be used as a catalyst in organic synthesis reactions.
Preparation Method:
The preparation of TMB usually involves a multi-step reaction. Specific methods are as follows:
1.2-bromo-5-formylthiophene and o-phenanthrazine bromide are reacted in benzene to obtain 2-formyl-5-carboxylic acid thiophene.
2. 2-formyl-5-carboxylic acid thiophene and sodium hydride are reacted to generate 2-formyl-5-carboxylic acid thiophene sodium salt.
3. reacting 2-formyl -5-carboxylic acid thiophene sodium salt with o-phenanthrazine bromide again to obtain 2-formyl -5-carboxylic acid thiophene o-phenanthrazine salt.
4. A precursor compound of TRMB is obtained by reacting with boric acid.
5. Finally, trifluoroacetic acid and methylamine were used to react to prepare TMB.
Safety Information:
The security of TMB has not been fully evaluated, so appropriate security measures need to be taken when handling and using TMB. As an organic compound, it may have certain toxicity and harmfulness to human body. During use, direct contact with skin, eyes and respiratory tract should be avoided. Wear appropriate personal protective equipment, such as lab gloves, goggles, and face shields. After operation, thoroughly clean and dispose of waste. If there is any discomfort or accident, should immediately seek medical treatment. In laboratory and industrial environments, relevant safe practices and guidelines should be followed.
Nature:
TRMB is a solid with a chemical formula of C18H24BF3NO2 and a relative molecular mass of 355.20g/mol. Its structure contains benzene and thiophene rings, as well as methylamine and trifluoroacetate ions.
Use:
TRMB is an important intermediate in organic synthesis. It can be used as a starting material for the synthesis of new drug molecules in medicinal chemistry. In addition, TRMB can also be used as a catalyst in organic synthesis reactions.
Preparation Method:
The preparation of TMB usually involves a multi-step reaction. Specific methods are as follows:
1.2-bromo-5-formylthiophene and o-phenanthrazine bromide are reacted in benzene to obtain 2-formyl-5-carboxylic acid thiophene.
2. 2-formyl-5-carboxylic acid thiophene and sodium hydride are reacted to generate 2-formyl-5-carboxylic acid thiophene sodium salt.
3. reacting 2-formyl -5-carboxylic acid thiophene sodium salt with o-phenanthrazine bromide again to obtain 2-formyl -5-carboxylic acid thiophene o-phenanthrazine salt.
4. A precursor compound of TRMB is obtained by reacting with boric acid.
5. Finally, trifluoroacetic acid and methylamine were used to react to prepare TMB.
Safety Information:
The security of TMB has not been fully evaluated, so appropriate security measures need to be taken when handling and using TMB. As an organic compound, it may have certain toxicity and harmfulness to human body. During use, direct contact with skin, eyes and respiratory tract should be avoided. Wear appropriate personal protective equipment, such as lab gloves, goggles, and face shields. After operation, thoroughly clean and dispose of waste. If there is any discomfort or accident, should immediately seek medical treatment. In laboratory and industrial environments, relevant safe practices and guidelines should be followed.
Last Update：2024-04-09 21:00:56
