(3beta,12beta,20R)-12,20-Dihydroxydammar-24-en-3-yl beta-D-glucopyranoside
20(R)Ginsenoside Rh2
CAS: 112246-15-8
Molecular Formula: C36H62O8
(3beta,12beta,20R)-12,20-Dihydroxydammar-24-en-3-yl beta-D-glucopyranoside - Names and Identifiers
(3beta,12beta,20R)-12,20-Dihydroxydammar-24-en-3-yl beta-D-glucopyranoside - Physico-chemical Properties
| Molecular Formula | C36H62O8 |
| Molar Mass | 622.88 |
| Density | 1.19 |
| Boling Point | 726.4±60.0 °C(Predicted) |
| Solubility | Easily soluble in water, methanol, ethanol, insoluble in benzene. |
| Appearance | White powder |
| pKa | 12.91±0.70(Predicted) |
| Storage Condition | 2-8℃ |
| MDL | MFCD22200425 |
| Physical and Chemical Properties | White powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from ginseng. |
(3beta,12beta,20R)-12,20-Dihydroxydammar-24-en-3-yl beta-D-glucopyranoside - Reference
| Reference Show more | 1. Cui Yong, Li Shiming, Jin Yan, et al. Effects of Ginsenoside Rh2 on airway inflammation in asthmatic mice [J]. Chinese Journal of Traditional Chinese Medicine 2016 031(007):2807-2811. 2. Li Xueqing, Li Li, Liu Xuefeng, etc. Study on the metabolism of Panax notoginseng saponins in human intestinal flora [J]. Pharmaceutical Biology technology, 2017(03):34-39. 3. Zhang, Hong-Mei, et al. "Global quality evaluation of commercial white and red ginsen using a UPLC-QTOF-MS/MS-based metabolomics approach." Journal of pharmaceutical and biomedical analysis 62 (2012): 258-273.https:// doi.org/10.1016/j. Jpba.2012. Hong Zhang, Jia-Ming Jiang, Dan Zheng, Ming Yuan, Zhi-Ying Wang, Hong-Mei Zhang, Chang-Wu Zheng, Lian-Bo Xiao, Hong-Xi Xu,A multidimensional analytical approach based on time-decoupled online comprehensive two-dimensional liquid chromatography coupled wit 5. Hong Zhang, Jia-Ming Jiang, Dan Zheng, Ming Yuan, Zhi-Ying Wang, Hong-Mei Zhang, Chang-Wu Zheng, Lian-Bo Xiao Hong-Xi Xu,A multidimensional analytical approach based on time-decoupled online comprehensive two-dimensional liquid chromatography coupled wit 6. Hong Zhang, Jia-Ming Jiang, Dan Zheng, Ming Yuan, Zhi-Ying Wang, Hong-Mei Zhang, Chang-Wu Zheng, Lian-Bo Xiao, Hong-Xi Xu,A multidimensional analytical approach based on time-decoupled online comprehensive two-dimensional liquid chromatography coupled wit 7. [IF=5.34] Shan-Shan Zhou et al."Stronger anti-obesity effect of white ginseng over red ginseng and the potential mechanisms involving chemically structural/compositional specificity to gut microbiota."Phytomedicine. 2020 Aug;74:152761 8. [IF=3.935] Hong-Mei Zhang et al."Holistic quality evaluation of commercial white and red ginseng using a UPLC-QTOF-MS/MS-based metabolomics approach."J Pharmaceut Biomed. 2012 Mar;62:258 9. [IF=3.935] Hong Zhang et al."A multidimensional analytical approach based on time-decoupled online comprehensive two-dimensional liquid chromatography coupled with ion mobility quadrupole time-of-flight mass spectrometry for the analysis of ginsenosides from white a 10. [IF=3.935] Shan-Shan Zhou et al."Synchronous characterization of carbohydrates and ginsenosides yields deeper insights into the processing chemistry of ginseng."J Pharmaceut Biomed. 2017 Oct;145:59 11. [IF=5.279] Yanan Gao et al."Galactosylation of Monosaccharide Derivatives of Glycyrrhetinic Acid by UDP-Glycosyltransferase GmSGT2 from Glycine max."J Agr Food Chem. 2020;68(32):8580-8588 12. [IF=4.411] Jianbo Chen et al."Neuroprotective Effects of Red Ginseng Saponins in Scopolamine-Treated Rats and Activity Screening Based on Pharmacokinetics."Molecules. 2019 Jan;24(11):2136 13. [IF=3.935] Ruimei Lin et al."Global identification and determination of the major constituents in Kai-Xin-San by ultra-performance liquid chromatography-quadrupole-Orbitrap mass spectrometry and gas chromatography-mass spectrometry."J Pharmaceut Biomed. 2021 Nov;206 14. [IF=2.547] Zhongyi Cong et al."Ginsenoside Rh3 Inhibits Proliferation and Induces Apoptosis of Colorectal Cancer Cells."Pharmacology. 2020;105(5-6):329-338 |
(3beta,12beta,20R)-12,20-Dihydroxydammar-24-en-3-yl beta-D-glucopyranoside - Reference Information
| biological activity | 20(R)-Ginsenoside Rh2, matrix metalloproteinase (MMP) inhibitor, as a cell anti-proliferative agent. It has anticancer effects by blocking cell proliferation and causing G1 phase arrest. 20(R)-Ginsenoside Rh2 induces apoptosis and has anti-inflammatory and antioxidant activities. 20(R)-Ginsenoside Rh2 inhibits the replication and proliferation of mouse and human gamma herpesvirus 68 (MHV-68), and the IC50 for mouse MHV-68 is 2.77 μM. |
| target | MMP |
| chemical properties | white powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from ginseng. |
| use | used for content determination/identification/pharmacological experiments, etc. Pharmacological effects: supplement vitality, nourish and strengthen. (20R)-ginsenoside Rh2 can inhibit the growth of tumor cells. |
Last Update：2024-04-09 21:49:45
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Product Name: 20(R)Ginsenoside Rh2 Visit Supplier Webpage Request for quotationCAS: 112246-15-8
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