(4-Nitrophenyl)methylsulfonyl chloride

(4-Nitrophenyl)methylsulfonyl chloride - Names and Identifiers

Name	(4-nitrophenyl)methanesulfonyl chloride
Synonyms	(4-Nitrophenyl)methanesulfonyl 1-(4-NITROBENZYLSULFONYL)CHLORIDE (4-Nitrophenyl)methylsulfonyl chloride (4-nitrophenyl)methanesulfonyl chloride (4-NITROPHENYL)METHANESULFONYL CHLORIDE (4-Nitrophenyl)methanesulfonyl chloride BENZENEMETHANESULFONYL CHLORIDE, 4-NITRO- (4-Nitrophenyl)methylsulphonyl chloride, tech
CAS	4025-75-6
EINECS	609-806-2
InChI	InChI=1/C7H6ClNO4S/c8-14(12,13)5-6-1-3-7(4-2-6)9(10)11/h1-4H,5H2

(4-Nitrophenyl)methylsulfonyl chloride - Physico-chemical Properties

Molecular Formula	C7H6ClNO4S
Molar Mass	235.64
Density	1.570±0.06 g/cm3(Predicted)
Melting Point	91-92°C
Boling Point	396.4±25.0 °C(Predicted)
Flash Point	193.6°C
Water Solubility	Reacts with water.
Vapor Presure	3.9E-06mmHg at 25°C
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Sensitive	Moisture Sensitive
Refractive Index	1.596
MDL	MFCD00034030

(4-Nitrophenyl)methylsulfonyl chloride - Risk and Safety

Risk Codes	R14 - Reacts violently with water R29 - Contact with water liberates toxic gas R34 - Causes burns R22 - Harmful if swallowed
Safety Description	S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S30 - Never add water to this product. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	UN3261
Hazard Class	8
Packing Group	II

(4-Nitrophenyl)methylsulfonyl chloride - Introduction

(4-nitrophenyl)methanesulfonyl chloride is an organic compound with a chemical formula of C7H6ClNO5S. It is a light yellow crystal with a spicy smell. The following is a detailed description of the nature, use, preparation and safety information of (4-nitrophenyl)methanesulfonyl chloride:

Nature:
-Appearance: light yellow crystal
-Odor: Spicy smell
-Melting point: about 130-132°C
-Boiling Point: 273-275°C
-Density: 1.54g/cm³ (20°C)
-Solubility: Soluble in organic solvents such as dimethyl sulfoxide and ethanol, insoluble in water

Use:
- (4-nitrophenyl)methanesulfonyl chloride is a commonly used organic synthesis reagent, which can be used to prepare other compounds, such as acylating agents and chlorinated reagents.
-In the field of medicinal chemistry and organic synthesis, it is usually used as a reagent to quench amine groups, which can convert amine groups into sulfonyl chloride functional groups to initiate reactions.
-It can also be used to synthesize biologically active compounds, such as drugs and dyes.

Preparation Method:
General method for preparing (4-nitrophenyl)methanesulfonyl chloride:
1. At low temperature, in the presence of sodium carbonate or potassium carbonate, p-nitrotoluene is reacted with sulfonyl chloride.
2. After completion of the reaction, crystals of the product were obtained by cooling and filtration.

Safety Information:
- (4-nitrophenyl)methanesulfonyl chloride irritant to skin, eyes and respiratory tract, rinse with plenty of water immediately after contact and seek medical help.
-it is a pungent odor substances, the operation should pay attention to avoid inhalation of its vapor.
-It is necessary to operate in a well-ventilated area and wear suitable protective equipment, such as gloves, glasses and protective masks.
-Keep away from fire and oxidant to avoid contact with combustibles.
-Storage should be sealed and placed in a cool, dry place, away from fire and acid.

Last Update：2024-04-09 15:17:57