(4-hydroxymethyl-benzyl)-carbamic acid ter-butyl ester

(4-hydroxymethyl-benzyl)-carbamic acid ter-butyl ester - Names and Identifiers

Name	(4-HYDROXYMETHYL-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER
Synonyms	4-(N-Boc-aminomethyl)benzyl alcohol N-Boc-4-(aminomethyl)benzyl Alcohol 4-(BOC-AMINOMETHYL-PHENYL)-METHANOL tert-BUTYL-4-(HYDROXYMETHYL)BENZYLCARBAMATE tert-butyl [4-(hydroxymethyl)benzyl]carbamate 4-(N-TERT-BUTOXYCARBONYLAMINOMETHYL)BENZYL ALCOHOL (4-hydroxymethyl-benzyl)-carbamic acid ter-butyl ester tert-butyl N-[[4-(hydroxymethyl)phenyl]methyl]carbamate (4-HYDROXYMETHYL-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER
CAS	123986-64-1
InChI	InChI=1/C13H19NO3/c1-13(2,3)17-12(16)14-8-10-4-6-11(9-15)7-5-10/h4-7,15H,8-9H2,1-3H3,(H,14,16)

(4-hydroxymethyl-benzyl)-carbamic acid ter-butyl ester - Physico-chemical Properties

Molecular Formula	C13H19NO3
Molar Mass	237.29
Density	1.106±0.06 g/cm3(Predicted)
Melting Point	98 °C
Boling Point	397.2±30.0 °C(Predicted)
Flash Point	194°C
Vapor Presure	5.08E-07mmHg at 25°C
pKa	12.19±0.46(Predicted)
Storage Condition	2-8°C
Refractive Index	1.528

(4-hydroxymethyl-benzyl)-carbamic acid ter-butyl ester - Risk and Safety

Hazard Symbols	Xi - Irritant
Hazard Note	Irritant

(4-hydroxymethyl-benzyl)-carbamic acid ter-butyl ester - Introduction

4-N-Boc-aminomethyl benzyl alcohol, also known as N-tert-butoxycarbonyl-4-aminomethyl benzyl alcohol, is an organic compound. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
4-N-Boc-aminomethylbenzyl alcohol is a solid having a white or white-like appearance. It is stable at room temperature and has low solubility. It has an acceptable melting point and heat of fusion, which allows it to undergo appropriate solid-phase synthesis and heat treatment in chemical synthesis.

Use:
4-N-Boc-aminomethyl benzyl alcohol is an important intermediate in organic synthesis. It is commonly used in the synthesis of peptides, drugs and other organic compounds. For example, it can be used to synthesize certain active compounds in the field of medicine, such as peptide hormones or anticancer drugs.

Preparation Method:
A commonly used method is to react benzethanone as a raw material with methylamine, then react with tert-butyl chloroformate, and then hydrolyze to obtain 4-N-Boc-aminomethyl benzyl alcohol.

Safety Information:
4-N-Boc-aminomethyl benzyl alcohol is relatively safe under correct handling and storage conditions. However, it may be irritating to the eyes, skin and respiratory system, so contact should be avoided when used. When handling this compound, it is recommended to wear appropriate protective equipment, such as chemical gloves and goggles. At the same time, care should be taken to avoid reacting with other chemicals or flammable substances. Safety practices shall be followed during handling and relevant hazard handling procedures shall be followed.

Last Update：2024-04-09 21:11:58