Molecular Formula | C20H22ClNO3 |
Molar Mass | 359.84658 |
Boling Point | 465.3°C at 760 mmHg |
Flash Point | 235.2°C |
Vapor Presure | 7.81E-09mmHg at 25°C |
Storage Condition | Room Temprature |
This product is 3-methyl-7-methoxy-2-phenyl-8-[ (dimethylchloromethyl) methylene] -4H-1-benzopyran-4-one hydrochloride. The content of C20H21NO3 • HC1 shall be between 97.0% and 102.0% calculated as the dry product.
take 0631g of this product, add water 30ml to dissolve, according to the law (General 4.0),pH value should be 6.0.
take 0.3g of this product and add 30ml of water to dissolve. The solution should be clarified.
take this product, precision weighing, adding mobile phase to dissolve and quantitatively dilute to make a solution containing about 0.16mg per lml as a test solution; Take 1ml for precision measurement, set in a 100ml measuring flask, dilute to the scale with the mobile phase, and shake to serve as a control solution. According to the chromatographic conditions under the content determination item, the sample solution and the control solution are respectively injected into the liquid chromatograph with precision, and the chromatogram is recorded to 2 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the sum of the impurity peak areas shall not be greater than 1.5 times (1.5%) of the main peak area of the control solution.
take about 0.1kg of this product, precision weighing, set in the top empty bottle, Precision Add 5ml of water, shake, as a test solution; Take the right amount of anhydrous ethanol, precision weighing, A solution containing about 100ug per 1 ml was prepared by quantitative dilution with water, and 5ml was accurately measured and placed in a headspace bottle as a reference solution. According to the determination method of residual solvent (General 0861 second method), using polyethylene glycol as stationary liquid capillary column; Column temperature is 40°C, maintained for 8 minutes, at a rate of 40°C per minute heating to 200°C, it was maintained for 5 minutes; The inlet temperature was 200°C; The detector temperature was 250°C; The headspace bottle equilibrium temperature was 80°C and the equilibrium time was 30 minutes. Take the reference solution and the test solution, respectively, and record the chromatogram. According to the external standard method to calculate the peak area, the residual amount of ethanol should comply with the provisions.
take this product, dry to constant weight at 107°C, weight loss shall not exceed 1.0% (General rule 0831).
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
take 0.5g of this product, add an appropriate amount of water to dissolve, add acetate buffer (pH 3.5)2ml, dilute it with water to 25ml, and check it according to law (General Principles 0821 first law), heavy metals should not be more than 20 parts per million.
measured by high performance liquid chromatography (General 0512).
silica gel bonded with eighteen alkyl silane was used as filler; Acetonitrile-water-ethylenediamine (50:25:0.2) was used as mobile phase; The detection wavelength was 243nm. The number of theoretical plates shall not be less than 1500 based on the peak of dimethylfurin.
take an appropriate amount of this product, accurately weigh it, add the mobile phase to dissolve and quantitatively dilute it to make a solution containing about 16ug per lml. Take a 20ul injection into the human liquid chromatograph for precise measurement and record the chromatogram; in addition, an appropriate amount of reference substance of dimethylfurin hydrochloride was determined by the same method. According to the external standard method to calculate the peak area, that is.
Central stimulant.
light shielding, sealed storage.