Name | 1-BROMO-2-BUTANONE |
Synonyms | 1-bromo-2-butanon 1-Brombutanon-(2) 1-BROMO-2-BUTANONE 1-bromo-butan-2-one Brommethylethylketon (BROMOMETHYL)ETHYL KETONE |
CAS | 816-40-0 |
EINECS | 212-431-3 |
Molecular Formula | C4H7BrO |
Molar Mass | 151 |
Density | 1.479 g/mL at 25 °C(lit.) |
Boling Point | 105 °C150 mm Hg(lit.) |
Flash Point | 155 °F |
Appearance | Liquid |
Color | Colorless to light yellow |
BRN | 741894 |
Storage Condition | Keep Cold |
Sensitive | Lachrymatory |
Refractive Index | n20/D 1.465(lit.) |
MDL | MFCD00000207 |
Physical and Chemical Properties | Specific gravity 1.479 |
Use | Bromobutanone is an important biomedical intermediate, which can be widely used in the synthesis of various drugs. Its small molecular weight and unique structure can derive a variety of downstream products. |
Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S27 - Take off immediately all contaminated clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
UN IDs | 1693 |
WGK Germany | 3 |
RTECS | EL7000000 |
HS Code | 29147000 |
Hazard Class | 6.1 |
Packing Group | III |
Downstream Products | METHYL 8-AMINO-2,3-DIMETHYLIMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLATE METHYLISOPSEUDOIONONE |
At present, there is no good scale-up production method for synthetic bromobutanone, which seriously hinders the development of its downstream products and its further development in the field of biomedicine. CN201310395732.0 provides a new method for synthesizing bromobutanone, which can overcome various unfavorable factors of bromobutanone in scale-up production, and has the characteristics of low raw materials, short route, use of no dangerous reagents, and high yield. The product can be generated on a large scale, and the price is low, which is easy to promote. The technical solution used by this patent to solve its technical problems is: using methyl 3-oxo-valerate as the starting material, after the chlorination and degreasing reaction to obtain the key intermediate, the yield is greater than 70%, and then brominated to obtain bromobutyl ketone, the total yield is greater than 50%.