(E)-3-(2-fluorophenyl)prop-2-enoyl chloride
(2E)-3-(2-Fluorophenyl)acryloyl chloride
CAS: 120681-05-2
Molecular Formula: C9H6ClFO
(E)-3-(2-fluorophenyl)prop-2-enoyl chloride - Names and Identifiers
(E)-3-(2-fluorophenyl)prop-2-enoyl chloride - Physico-chemical Properties
| Molecular Formula | C9H6ClFO |
| Molar Mass | 184.59 |
| Storage Condition | Room Temprature |
| Sensitive | Irritant |
| MDL | MFCD03421465 |
(E)-3-(2-fluorophenyl)prop-2-enoyl chloride - Risk and Safety
| Hazard Class | IRRITANT |
(E)-3-(2-fluorophenyl)prop-2-enoyl chloride - Introduction
(2E)-3-(2-Fluorophenyl)acryloyl chloride ((2E)-3-(2-fluorophenyl) acryloyl chloride) is an organic compound. The following is its nature, use, preparation and safety information:
Nature:
-Appearance: colorless or yellowish liquid
-Molecular formula: C10H6ClFO
-Molecular Weight: 194.60
-Melting Point: 54-56°C
-Boiling Point: 279-281°C
-Density: 1.245 g/mL at 25°C
-Solubility: Soluble in organic solvents such as chloroform, ether and dichloromethane.
Use:
(2E)-3-(2-Fluorophenyl)acryloyl chloride is an important organic compound, often used in the synthesis of other compounds. It can be used as an intermediate:
-Drug synthesis: It can be used to synthesize compounds with biological activity, such as antibacterial agents, anti-tumor drugs, etc.
-pesticide synthesis: pesticide manufacturing can be applied to the chemical synthesis process.
Preparation Method:
(2E)-3-(2-Fluorophenyl)acryloyl chloride can be prepared by the following method:
First, (2E)-3-(2-Fluorophenyl)acrylic acid can be synthesized using benzoic acid and chloroacetic anhydride. Then, the (2E)-3-(2-Fluorophenyl)acrylic acid used as a raw material was reacted with thionyl chloride to form (2E)-3-(2-Fluorophenyl)acryloyl chloride.
Safety Information:
(2E)-3-(2-Fluorophenyl)acryloyl chloride is an irritating and corrosive substance, and it is necessary to pay attention to safety when used. Contact with skin, eyes, or respiratory tract may cause irritation and injury. Appropriate personal protective equipment should be worn during operation to ensure good ventilation. Avoid inhalation, ingestion or skin contact during use. In case of accidental contact, rinse immediately with plenty of water and seek medical help.
Nature:
-Appearance: colorless or yellowish liquid
-Molecular formula: C10H6ClFO
-Molecular Weight: 194.60
-Melting Point: 54-56°C
-Boiling Point: 279-281°C
-Density: 1.245 g/mL at 25°C
-Solubility: Soluble in organic solvents such as chloroform, ether and dichloromethane.
Use:
(2E)-3-(2-Fluorophenyl)acryloyl chloride is an important organic compound, often used in the synthesis of other compounds. It can be used as an intermediate:
-Drug synthesis: It can be used to synthesize compounds with biological activity, such as antibacterial agents, anti-tumor drugs, etc.
-pesticide synthesis: pesticide manufacturing can be applied to the chemical synthesis process.
Preparation Method:
(2E)-3-(2-Fluorophenyl)acryloyl chloride can be prepared by the following method:
First, (2E)-3-(2-Fluorophenyl)acrylic acid can be synthesized using benzoic acid and chloroacetic anhydride. Then, the (2E)-3-(2-Fluorophenyl)acrylic acid used as a raw material was reacted with thionyl chloride to form (2E)-3-(2-Fluorophenyl)acryloyl chloride.
Safety Information:
(2E)-3-(2-Fluorophenyl)acryloyl chloride is an irritating and corrosive substance, and it is necessary to pay attention to safety when used. Contact with skin, eyes, or respiratory tract may cause irritation and injury. Appropriate personal protective equipment should be worn during operation to ensure good ventilation. Avoid inhalation, ingestion or skin contact during use. In case of accidental contact, rinse immediately with plenty of water and seek medical help.
Last Update：2024-04-09 21:01:54
