(R)-(+)-5,5',6,6'-Tetramethyl-3,3'-di-t-butyl-1,1'-biphenyl-2,2'-diol
(R)-(+)-5,5',6,6'-Tetramethyl-3,3'-di-t-butyl-1,1'-biphenyl-2,2'-diol
CAS: 329735-68-4
Molecular Formula: C24H34O2
(R)-(+)-5,5',6,6'-Tetramethyl-3,3'-di-t-butyl-1,1'-biphenyl-2,2'-diol - Names and Identifiers
| Name | (R)-(+)-5,5',6,6'-Tetramethyl-3,3'-di-t-butyl-1,1'-biphenyl-2,2'-diol |
| Synonyms | BIPHEN H2 (R) BIPHEN H2 (R)-(+)-BIPHEN H2 R-3,3'-Di-tert-butyl-5,5',6,6'-tetraMethylbiphenyl-2,2'-diol (R)-(+)-5,5',6,6'-Tetramethyl-3,3'-di-t-butyl-1,1'-biphenyl-2,2'-diol (S)-(-)-5,5',6,6'-TETRAMETHYL-3,3'-DI-T-BUTYL-1,1'-BIPHENYL-2,2'-DIOL (R)-(+)-5,5',6,6'-Tetramethyl-3,3'-di-t-butyl-1,1'-biphenyl-2,2'-diol, (R) BIPH |
| CAS | 329735-68-4 |
(R)-(+)-5,5',6,6'-Tetramethyl-3,3'-di-t-butyl-1,1'-biphenyl-2,2'-diol - Physico-chemical Properties
| Molecular Formula | C24H34O2 |
| Molar Mass | 354.53 |
| Density | 1.012±0.06 g/cm3(Predicted) |
| Melting Point | 170-174°C |
| Boling Point | 420.8±45.0 °C(Predicted) |
| Specific Rotation(α) | +78° (c 0.352, THF) |
| Appearance | Powder |
| Color | white |
| pKa | 10.95±0.50(Predicted) |
| Storage Condition | 2-8°C |
(R)-(+)-5,5',6,6'-Tetramethyl-3,3'-di-t-butyl-1,1'-biphenyl-2,2'-diol - Risk and Safety
| WGK Germany | 3 |
(R)-(+)-5,5',6,6'-Tetramethyl-3,3'-di-t-butyl-1,1'-biphenyl-2,2'-diol - Introduction
(R)-( )-5,5 ',6,6'-Tetramethyl-3,3 '-di-t-butyl-1,1'-biphenyl-2,2 '-diol ((R)-( )-5,5',6,6 '-Tetramethyl-3,3'-di-t-butyl-1,1 '-biphenyl-2,2'-diol) is a chiral compound with the following properties:
Appearance: Colorless crystalline solid
Molecular formula: C34H42O2
Molecular weight: 482.70g/mol
Density: 1.07g/cm3
Melting point: 245-248°C
optical rotation:[α]D 36.0 ° (c = 1, CHCl3)
The main uses of (R)-( )-5,5 ',6,6'-Tetramethyl-3,3 '-di-t-butyl-1,1'-biphenyl-2,2 '-diol are as follows:
1. Chiral reagents: used for stereoselective changes in organic synthesis reactions, such as chiral catalysis, chiral ligand synthesis, etc.
2. drug synthesis: as a drug intermediate for the preparation of drugs with chiral activity.
3. coating additives: can be used as anti-aging agent, high temperature antioxidant and polymer additives.
The method for preparing (R)-( )-5,5 ',6,6'-Tetramethyl-3,3 '-di-t-butyl-1,1'-biphenyl-2,2 '-diol mainly includes the following steps:
1. The phenyl hydroxy compound dimethylanisole (4,4 '-Dimethoxy-1,1'-biphenyl) is methylated by a methylation reaction.
2. The resulting methylated product was subjected to a remethylation reaction to obtain 3,3 '-dimethyl-5, 5',6,6 '-tetramethylbiphenyl-2,2'-diol (3,3 '-Dimethyl-5,5',6,6 '-tetramethylbiphenyl-2,2'-diol).
3. Finally, (R)-( )-5,5 ',6,6'-Tetramethyl-3,3 '-di-t-butyl-1,1'-biphenyl-2,2 '-diol is obtained by a substitution reaction of the para group on 3,3'-dimethyl-5, 5 ',6,6'-tetramethylbiphenyl-2, 2 '-diol.
Regarding the safety information of this compound, there is currently no specific toxicity data report, but in general, please follow laboratory safety procedures and keep the compound away from open flames and high temperatures. Please wear appropriate personal protective equipment when using and storing, and ensure that the work area is well ventilated. If you have any special requirements, please refer to the relevant safety data sheet of the compound.
Appearance: Colorless crystalline solid
Molecular formula: C34H42O2
Molecular weight: 482.70g/mol
Density: 1.07g/cm3
Melting point: 245-248°C
optical rotation:[α]D 36.0 ° (c = 1, CHCl3)
The main uses of (R)-( )-5,5 ',6,6'-Tetramethyl-3,3 '-di-t-butyl-1,1'-biphenyl-2,2 '-diol are as follows:
1. Chiral reagents: used for stereoselective changes in organic synthesis reactions, such as chiral catalysis, chiral ligand synthesis, etc.
2. drug synthesis: as a drug intermediate for the preparation of drugs with chiral activity.
3. coating additives: can be used as anti-aging agent, high temperature antioxidant and polymer additives.
The method for preparing (R)-( )-5,5 ',6,6'-Tetramethyl-3,3 '-di-t-butyl-1,1'-biphenyl-2,2 '-diol mainly includes the following steps:
1. The phenyl hydroxy compound dimethylanisole (4,4 '-Dimethoxy-1,1'-biphenyl) is methylated by a methylation reaction.
2. The resulting methylated product was subjected to a remethylation reaction to obtain 3,3 '-dimethyl-5, 5',6,6 '-tetramethylbiphenyl-2,2'-diol (3,3 '-Dimethyl-5,5',6,6 '-tetramethylbiphenyl-2,2'-diol).
3. Finally, (R)-( )-5,5 ',6,6'-Tetramethyl-3,3 '-di-t-butyl-1,1'-biphenyl-2,2 '-diol is obtained by a substitution reaction of the para group on 3,3'-dimethyl-5, 5 ',6,6'-tetramethylbiphenyl-2, 2 '-diol.
Regarding the safety information of this compound, there is currently no specific toxicity data report, but in general, please follow laboratory safety procedures and keep the compound away from open flames and high temperatures. Please wear appropriate personal protective equipment when using and storing, and ensure that the work area is well ventilated. If you have any special requirements, please refer to the relevant safety data sheet of the compound.
Last Update：2024-04-09 21:54:55
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