(R)-(+)-N-Boc-2-Piperidinecarboxylic Acid
Boc-D-Homopro-OH
CAS: 28697-17-8
Molecular Formula: C11H19NO4
(R)-(+)-N-Boc-2-Piperidinecarboxylic Acid - Names and Identifiers
(R)-(+)-N-Boc-2-Piperidinecarboxylic Acid - Physico-chemical Properties
| Molecular Formula | C11H19NO4 |
| Molar Mass | 229.27 |
| Density | 1.164±0.06 g/cm3(Predicted) |
| Melting Point | 116-119°C(lit.) |
| Boling Point | 353.2±35.0 °C(Predicted) |
| Specific Rotation(α) | 68 º (c=1 in acetic acid) |
| Solubility | Soluble in 2ml dimethyl formamide 0.3gram. |
| Appearance | Crystalline Powder |
| Color | White to brown |
| BRN | 480023 |
| pKa | 4.03±0.20(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
(R)-(+)-N-Boc-2-Piperidinecarboxylic Acid - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 29339900 |
| Hazard Class | IRRITANT |
(R)-(+)-N-Boc-2-Piperidinecarboxylic Acid - Introduction
Boc-D-Homopro-OH(Boc-D-Homopro-OH) is an organic compound with the following properties:
1. Appearance: White crystalline solid or powder.
2. Molecular formula: C13H21NO4.
3. Molecular weight: 259.31g/mol.
4. Melting point: About 85-87 ° C.
5. Solubility: Soluble in some organic solvents, such as dichloromethane, methanol and dimethylformamide.
Boc-D-Homopro-OH is mainly used for amino protecting agent in organic synthesis. Its main applications include:
1. It can be used as an intermediate for the synthesis of small molecular compounds with biological activity.
2. Can be used as amino acid protecting group, used in organic synthesis of peptide synthesis.
3. Can be used to synthesize containing piperidine structure of natural products or drugs.
The preparation of Boc-D-Homopro-OH is usually carried out by the following steps:
1. Mix 2-formic acid piperidine with nitric acid and react at low temperature to generate nitrate.
2. React the generated nitrate with O-butyldimethylsilanamide (Boc2O) to generate Boc-D-Homopro-OH.
Regarding safety information, Boc-D-Homopro-OH is a chemical substance and needs to be paid attention to its safe operation:
1. Wear appropriate personal protective equipment such as lab gloves and goggles during use.
2. Avoid prolonged contact with skin and inhalation of its dust.
3. The operation should be carried out in a well-ventilated laboratory.
4. Storage should be placed in a dry, cool place, and avoid contact with oxidants.
When using chemicals, it is recommended to follow the correct operating procedures and safety precautions, and operate under the guidance of laboratory professionals.
1. Appearance: White crystalline solid or powder.
2. Molecular formula: C13H21NO4.
3. Molecular weight: 259.31g/mol.
4. Melting point: About 85-87 ° C.
5. Solubility: Soluble in some organic solvents, such as dichloromethane, methanol and dimethylformamide.
Boc-D-Homopro-OH is mainly used for amino protecting agent in organic synthesis. Its main applications include:
1. It can be used as an intermediate for the synthesis of small molecular compounds with biological activity.
2. Can be used as amino acid protecting group, used in organic synthesis of peptide synthesis.
3. Can be used to synthesize containing piperidine structure of natural products or drugs.
The preparation of Boc-D-Homopro-OH is usually carried out by the following steps:
1. Mix 2-formic acid piperidine with nitric acid and react at low temperature to generate nitrate.
2. React the generated nitrate with O-butyldimethylsilanamide (Boc2O) to generate Boc-D-Homopro-OH.
Regarding safety information, Boc-D-Homopro-OH is a chemical substance and needs to be paid attention to its safe operation:
1. Wear appropriate personal protective equipment such as lab gloves and goggles during use.
2. Avoid prolonged contact with skin and inhalation of its dust.
3. The operation should be carried out in a well-ventilated laboratory.
4. Storage should be placed in a dry, cool place, and avoid contact with oxidants.
When using chemicals, it is recommended to follow the correct operating procedures and safety precautions, and operate under the guidance of laboratory professionals.
Last Update：2024-04-09 19:05:48
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