(R)-3-FLUORO-PYRROLIDINE HCL

(R)-3-FLUORO-PYRROLIDINE HCL - Names and Identifiers

Name	(3R)-3-fluoropyrrolidine hydrochloride
Synonyms	3-FLUORO PYRROLIDINE HCL 3(R)-fluoropyrrolidine(HCl) (R)-3-Fluoropyrrolidine HCl (R)-3-FLUORO-PYRROLIDINE HCL (R)-3-Fluoro-pyrrolidine HCl salt (R)-3-FLUOROPYRROLIDINE HYDROCHLORIDE (3R)-3-fluoropyrrolidine hydrochloride (R)-(-)-3-FLUOROPYRROLIDINE HYDROCHLORIDE (3R)-(-)-3-Fluoropyrrolidine hydrochloride
CAS	136725-55-8
InChI	InChI=1/C4H8FN.ClH/c5-6-3-1-2-4-6;/h1-4H2;1H

(R)-3-FLUORO-PYRROLIDINE HCL - Physico-chemical Properties

Molecular Formula	C4H9ClFN
Molar Mass	125.57
Melting Point	179-186°C
Boling Point	131.7°C at 760 mmHg
Flash Point	33.5°C
Vapor Presure	8.27mmHg at 25°C
Appearance	Crystalline powder
Storage Condition	Inert atmosphere,Room Temperature
Sensitive	Moisture Sensitive
MDL	MFCD04038717

(R)-3-FLUORO-PYRROLIDINE HCL - Risk and Safety

Risk Codes	R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany	3
TSCA	N
HS Code	29339900
Hazard Note	Moisture Sensitive
Hazard Class	IRRITANT

(R)-3-FLUORO-PYRROLIDINE HCL - Introduction

3-(R)-Fluoropyrrolidine hydrochloride is an organic compound with the chemical formula C4H7FN2 · HCl. The following is a description of the properties, uses, preparation and safety information of the compound:

Properties: 3-(R)-fluoropyrrolidine hydrochloride is a colorless crystalline solid with a special stereo configuration. Its molecule contains a fluorine atom and a pyrrolidine ring. It is not sensitive to light and air at room temperature, but may be decomposed at high temperatures. It is soluble in water, ethanol and ether solvents.

Uses: 3-(R)-fluoropyrrolidine hydrochloride is mainly used for chiral resolution and chiral analysis in pharmaceutical synthesis. It is a common intermediate for the resolution of chiral drugs and has a wide range of applications, including pharmaceuticals, pesticides and fine chemicals.

Preparation method: A common synthesis method is to prepare 3-(R)-fluoropyrrolidine by reacting 2-chloropyrrolidine with hydrogen fluoride, and then react it with hydrochloric acid to obtain hydrochloride. The specific synthesis method can also be adjusted according to the specific requirements and reaction conditions.

Safety information: 3-(R)-fluoropyrrolidine hydrochloride has low toxicity, but it is still necessary to pay attention to safe operation. Wear protective glasses and gloves during operation to avoid skin contact, inhalation or ingestion. During use and storage, avoid open flames and high temperatures, and keep them properly to avoid contact with strong oxidants and combustibles. In case of accidental contact or ingestion, please consult a doctor and inform the doctor of the detailed information of the relevant compound.

Last Update：2024-04-09 18:58:34