(R)-4-(TERT-BUTOXYCARBONYL)PIPERAZINE-2-CARBOXYLIC ACID

(R)-4-(TERT-BUTOXYCARBONYL)PIPERAZINE-2-CARBOXYLIC ACID - Names and Identifiers

Name	4-BOC-PIPERAZINE-2-(R)-CARBOXYLIC ACID
Synonyms	B35611 (4-N-BOC)PIPERAZINE(2R) COOH R-4-Boc-piperazine-2-carboxylic acid 4-BOC-PIPERAZINE-2-(R)-CARBOXYLIC ACID (S)-4-Boc-2-piperazine carboxylic acid (R)-4-BOC-PIPERAZINE-2-CARBOXYLIC ACID (R)-4-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID (R)-PIPERAZINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER (R)-4-(TERT-BUTOXYCARBONYL)PIPERAZINE-2-CARBOXYLIC ACID (2R)-4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid (2S)-4-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid 1,3-Piperazinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (3S)- (2S)-4-{[(2-Methyl-2-propanyl)oxy]carbonyl}-2-piperazinecarboxylic acid
CAS	192330-11-3
InChI	InChI=1/C10H18N2O4/c1-10(2,3)16-9(15)12-5-4-11-7(6-12)8(13)14/h7,11H,4-6H2,1-3H3,(H,13,14)/t7-/m1/s1

(R)-4-(TERT-BUTOXYCARBONYL)PIPERAZINE-2-CARBOXYLIC ACID - Physico-chemical Properties

Molecular Formula	C10H18N2O4
Molar Mass	230.26
Density	1.193±0.06 g/cm3(Predicted)
Melting Point	231-239 ºC
Boling Point	371.8±37.0 °C(Predicted)
Flash Point	178.6°C
Vapor Presure	1.5E-06mmHg at 25°C
pKa	2.20±0.20(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,Room temperature
Refractive Index	1.495

(R)-4-(TERT-BUTOXYCARBONYL)PIPERAZINE-2-CARBOXYLIC ACID - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R43 - May cause sensitization by skin contact R36 - Irritating to the eyes
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S36/37 - Wear suitable protective clothing and gloves.

(R)-4-(TERT-BUTOXYCARBONYL)PIPERAZINE-2-CARBOXYLIC ACID - Introduction

4-boc-piperine-2-(R)-CARBOXYLIC ACID, chemically named (R)-acid, is an organic compound containing a piperazine ring.

Nature:
The chemical formula of 4-BOC-PIPERAZINE-2-(R)-CARBOXYLIC ACID is C10H18N2O4, and the relative molecular mass is 238.26g/mol. It is a white crystalline solid, soluble in some organic solvents such as dichloromethane and ethanol. It has a melting point of about 126-128°C.

Use:
4-BOC-PIPERAZINE-2-(R)-CARBOXYLIC ACID is commonly used as an intermediate and protecting group in organic synthesis. It can be used to synthesize a variety of bioactive molecules, such as drugs, biological materials and pesticides. Because of its stereoselectivity, it can be used as a precursor of chiral catalyst for catalytic asymmetric synthesis.

Method:
4-BOC-PIPERAZINE-2-(R)-CARBOXYLIC ACID can be prepared by reacting piperazine with (Boc)2O under basic conditions. Piperazine is first dissolved in acetonitrile or methanol, a base catalyst such as triethylamine is added, (Boc)2O is added, and after completion of the reaction, hydrolysis acidification is carried out to obtain the target product.

Safety Information:
4-BOC-PIPERAZINE-2-(R)-carboxy ACID is generally low in toxicity and irritation, but it still needs to be operated according to laboratory standards. Contact with oxidizing agents, strong acids or strong bases should be avoided during handling and storage. Avoid direct contact with skin and eyes and wear appropriate personal protective equipment when using. If taken by mistake or inhaled by mistake, seek medical attention immediately.

Last Update：2024-04-09 21:04:16