(S)-2,4-diaminobutanoic acid
L-DAB HBR
CAS: 1758-80-1
Molecular Formula: C4H10N2O2
(S)-2,4-diaminobutanoic acid - Names and Identifiers
| Name | L-DAB HBR |
| Synonyms | L-DABA L-Dab? H-DabHBr H-Dab·HBr L-DAB HBR L-DAB HYDROBROMIDE L-2,4-Diaminobutanoate 2,4-diaminobutanoic acid (S)-2,4-Diaminobutyric acid (S)-2,4-diaminobutanoic acid (2S)-2,4-diaminobutanoic acid L-2,4-DIAMINOBUTYRIC ACID HYDROBROMIDE |
| CAS | 1758-80-1 |
| EINECS | 206-166-2 |
| InChI | InChI=1/C4H10N2O2/c5-2-1-3(6)4(7)8/h3H,1-2,5-6H2,(H,7,8)/t3-/m0/s1 |
(S)-2,4-diaminobutanoic acid - Physico-chemical Properties
| Molecular Formula | C4H10N2O2 |
| Molar Mass | 118.13 |
| Density | 1.218±0.06 g/cm3(Predicted) |
| Melting Point | 216-218 °C |
| Boling Point | 321.0±32.0 °C(Predicted) |
| Flash Point | 147.9°C |
| Vapor Presure | 6.36E-05mmHg at 25°C |
| pKa | 2.00±0.10(Predicted) |
| Storage Condition | 2-8°C(protect from light) |
| Refractive Index | 1.513 |
| In vitro study | The tumor cells are irreversibly and totally damaged by incubation with 10 mM L-2,4-Diaminobutyric acid for 24 h at 37°C. The cell-destructive effect by L-DABA is probably due to an osmotic lysis induced by the non-saturated intracellular accumulation of L-DABA. The harmful effect of L-DABA could be abolished by concomitant incubation with L-alanine and L-methionine. Kinetic studies indicates that L-DABA is a non-linear, non-competitive inhibitor of GABA transaminase activity. The L-DABA-induced elevation of GABA levels parallels the inhibition of GABA transaminase activity. L-2,4-Diaminobutyric acid, an amino acid analogue, produceS a cytolytic effect with a human glioma cell line, SKMG-1, and normal human fibroblasts. The concentrations of L-DABA necessary to reduce the cell count to 50% of control following a 24-h incubation at 37°C are 12.5 mM for the human fibroblasts and 20 mM for the glioma cell line. |
| In vivo study | Treatment with L-DABA results in 43.4% reduction of tumor growth. L-DABA is a more effective inhibitor of GABA transaminase in vivo than in vitro . |
(S)-2,4-diaminobutanoic acid - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 5.024 ml | 25.12 ml | 50.24 ml |
| 5 mM | 1.005 ml | 5.024 ml | 10.048 ml |
| 10 mM | 0.502 ml | 2.512 ml | 5.024 ml |
| 5 mM | 0.1 ml | 0.502 ml | 1.005 ml |
Last Update：2024-01-02 23:10:35
(S)-2,4-diaminobutanoic acid - Reference Information
| Biological activity | L-DABA (L-2,4-Diaminobutyric acid) is a weak inhibitor of GABA transaminase with an IC50 value greater than 500 μM. It has anti-tumor activity in vivo and in vitro. |
Last Update：2024-04-09 20:52:54
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