(S)-2-(4-Chlorophenyl)-2-hydroxyacetic acid

(S)-2-(4-Chlorophenyl)-2-hydroxyacetic acid - Names and Identifiers

Name	L-4-chloro mandelic acid
Synonyms	L-4-chloro Mandelic acid L-4-chloro mandelic acid (S)-4-CHLOROMANDELIC ACID S-(+)-4-chloro mandelic acid (S)-2-(4-Chlorophenyl)-2-hydroxyacetic acid Benzeneacetic acid, 4-chloro-α-hydroxy-, (αS)-
CAS	76496-63-4
EINECS	1312995-182-4

(S)-2-(4-Chlorophenyl)-2-hydroxyacetic acid - Physico-chemical Properties

Molecular Formula	C8H7ClO3
Molar Mass	186.59
Density	1.468±0.06 g/cm3(Predicted)
Melting Point	113 - 116°C
Boling Point	361.4±27.0 °C(Predicted)
Solubility	Methanol (Slightly), Water (Slightly)
Appearance	Solid
Color	White to Off-White
pKa	3.14±0.10(Predicted)
Storage Condition	Sealed in dry,Room Temperature
MDL	MFCD00798439

(S)-2-(4-Chlorophenyl)-2-hydroxyacetic acid - Introduction

L-4-chloro mandelic acid is an organic compound with the chemical formula C8H9ClO3. It is a white crystalline powder with a special bitter taste. L-4-chloro mandelic acid has a melting point of 133-135°C and a low solubility in water.

L-4-chloro mandelic acid is often used as a raw material of chiral recognition agents for the separation and detection of chiral compounds. It can also be used as an intermediate in drug synthesis for the synthesis of potentially biologically active molecules.

There are various methods for preparing L-4-chloro mandelic acid. One of the main methods of preparation is by the reaction of salicylaldehyde and chloroacetic acid. This reaction is carried out using L-alanine as a catalyst, and the product can be obtained in high yield and high enantioselectivity.

For safety information, L-4-chloro mandelic acid has low toxicity in general. However, as a chemical, appropriate protective measures should be taken, such as wearing protective glasses and gloves. Avoid inhalation of dust or contact with skin during use. Appropriate environmental and safety procedures should be followed when disposing of waste. Specific safety information and operating precautions should be determined from the specific Material Safety Data Sheet (MSDS).

Last Update：2024-04-09 20:02:46