(S)-N-Boc-3-cyanopyrrolidine
(S)-1-BOC-3-Cyanopyrrolidine
CAS: 132945-78-9
Molecular Formula: C10H16N2O2
(S)-N-Boc-3-cyanopyrrolidine - Names and Identifiers
| Name | (S)-1-BOC-3-Cyanopyrrolidine |
| Synonyms | (S)-N-Boc-3-cyanopyrrolidine (S)-1-BOC-3-Cyanopyrrolidine N-T-BOC-3(S)-CYANOPYRROLIDINE (S)-1-N-BOC-3-CYANO-PYRROLIDINE (S)-tert-butyl 3-cyanopyrrolidine-1-carboxylate (S)-TERT-BUTYL-3-CYANOPYRROLIDINE-1-CARBOXYLATE (S)-1-N-(tert-Butoxycarbonyl)-3-cyanopyrrolidine tert-butyl (3S)-3-cyanopyrrolidine-1-carboxylate (S)-3-CYANO-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER |
| CAS | 132945-78-9 |
| InChI | InChI=1/C10H16N2O2/c1-10(2,3)14-9(13)12-5-4-8(6-11)7-12/h8H,4-5,7H2,1-3H3/t8-/m1/s1 |
| InChIKey | VDDMCMFPUSCJNA-MRVPVSSYSA-N |
(S)-N-Boc-3-cyanopyrrolidine - Physico-chemical Properties
| Molecular Formula | C10H16N2O2 |
| Molar Mass | 196.25 |
| Density | 1.08±0.1 g/cm3(Predicted) |
| Boling Point | 307.9±35.0 °C(Predicted) |
| Flash Point | 140°C |
| Vapor Presure | 0.000703mmHg at 25°C |
| Appearance | White to Brown Liquid or Solid |
| pKa | -3.73±0.40(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Sensitive | Sensitive to humidity and light |
| Refractive Index | 1.488 |
| MDL | MFCD03419277 |
(S)-N-Boc-3-cyanopyrrolidine - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
(S)-N-Boc-3-cyanopyrrolidine - Introduction
(S)-1-Boc-3-cyanopyrrolidine is an organic compound with the chemical name (S)-N-Boc-3-cyanopyrrolidine.
The properties of the compound include physical properties and chemical properties. In terms of physical properties, its molecular formula is C9H15N3O2, its relative molecular mass is 197.23, and its appearance is a white crystalline solid with a special smell. In terms of chemical properties, it is stable at room temperature and can be hydrolyzed under alkaline conditions.
(S)-1-Boc-3-cyanopyrrolidine is commonly used as a catalyst and an intermediate in organic synthesis. It can be used as a reagent in a variety of organic synthesis reactions, such as: carbonic reaction, substitution reaction and cycloaddition reaction.
The process for the preparation of (S)-1-Boc-3-cyanopyrrolidine is generally achieved by a condensation reaction. A common preparation method is to condense 3-cyanopyrrolidine with (S)-α-benzylaminopyruvate in the presence of a base to obtain the desired product followed by the step of protecting the hydroxyl group.
Safety precautions are required when using (S)-1-Boc-3-cyanopyrrolidine. It is an organic compound and has certain toxicity. Therefore, appropriate personal protective equipment such as gloves and goggles should be worn during operation to avoid contact with skin, eyes and inhalation. At the same time, it should be operated under well-ventilated laboratory conditions to avoid the accumulation of harmful gases or vapors.
The properties of the compound include physical properties and chemical properties. In terms of physical properties, its molecular formula is C9H15N3O2, its relative molecular mass is 197.23, and its appearance is a white crystalline solid with a special smell. In terms of chemical properties, it is stable at room temperature and can be hydrolyzed under alkaline conditions.
(S)-1-Boc-3-cyanopyrrolidine is commonly used as a catalyst and an intermediate in organic synthesis. It can be used as a reagent in a variety of organic synthesis reactions, such as: carbonic reaction, substitution reaction and cycloaddition reaction.
The process for the preparation of (S)-1-Boc-3-cyanopyrrolidine is generally achieved by a condensation reaction. A common preparation method is to condense 3-cyanopyrrolidine with (S)-α-benzylaminopyruvate in the presence of a base to obtain the desired product followed by the step of protecting the hydroxyl group.
Safety precautions are required when using (S)-1-Boc-3-cyanopyrrolidine. It is an organic compound and has certain toxicity. Therefore, appropriate personal protective equipment such as gloves and goggles should be worn during operation to avoid contact with skin, eyes and inhalation. At the same time, it should be operated under well-ventilated laboratory conditions to avoid the accumulation of harmful gases or vapors.
Last Update：2024-04-10 22:29:15
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CAS: 132945-78-9
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CAS: 132945-78-9
Tel: 18301782025
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Mobile: 18021002903
QQ: 3008007409
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