-KE-298
S-methyl-KE-298
CAS: 143584-75-2
Molecular Formula: C13H16O3S
-KE-298 - Names and Identifiers
| Name | S-methyl-KE-298 |
| Synonyms | -KE-298 S-methyl-KE-298 |
| CAS | 143584-75-2 |
-KE-298 - Physico-chemical Properties
| Molecular Formula | C13H16O3S |
| Molar Mass | 252.33 |
| Solubility | H2O |
| Storage Condition | -20℃ |
| In vitro study | S-methyl-KE-298 is a methyl conjugate of deacetyl-KE-298 is plasma. In vitro protein binding of KE-298 and its plasma metabolites, deacetyl-KE-298 (M-1) and S-methyl-KE-298 (M-2), is high in rat (>97%), dog (>89%) and human plasma (>99%), respectively. KE-298 blocks this IL-1β-induced pro-MMP-2 activation and MT1-MMP expression, but does not affect IL-1β-induced tissue inhibitor of metalloproteinase-2 (TIMP-2) secretion from rheumatoid synovial cells. KE-298 inhibits MMP-1 production from rheumatoid arthritis (RA) synovial cells by affecting a transcription factor, AP-1. KE-298 inhibits the basal levels of MT1-MMP expression of unstimulated rheumatoid synovial cells. |
-KE-298 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.963 ml | 19.815 ml | 39.631 ml |
| 5 mM | 0.793 ml | 3.963 ml | 7.926 ml |
| 10 mM | 0.396 ml | 1.982 ml | 3.963 ml |
| 5 mM | 0.079 ml | 0.396 ml | 0.793 ml |
Last Update：2024-01-02 23:10:35
-KE-298 - Reference Information
| biological activity | S-methyl-KE-298 is an active metabolite of KE-298. KE-298 inhibits the production of matrix metalloproteinases (MMP-1) by rheumatoid arthritis (RA) synoviocytes. |
Last Update：2024-04-09 21:49:45
Supplier List
Spot supply
Product Name: S-methyl-KE-298 Visit Supplier Webpage Request for quotationCAS: 143584-75-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: S-methyl-KE-298 Visit Supplier Webpage Request for quotationCAS: 143584-75-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History