1,2-Dimethoxybenzene
Veratrole
CAS: 91-16-7
Molecular Formula: C8H10O2
1,2-Dimethoxybenzene - Names and Identifiers
| Name | Veratrole |
| Synonyms | ODMB Veratrole FEMA 3799 o-Dimethoxybenzene 1,2-Dimethoxybenzen 1,2-Dimethoxybenzene DIMETHYLPYROCATECHIN 1,2-DIMETHOXYBENZENE GUAIACOL METHYL ETHER CATECHOL DIMETHYL ETHER VERATROLE PESTANAL (1,2-DIMETHOXYBENZENE |
| CAS | 91-16-7 |
| EINECS | 202-045-3 |
| InChI | InChI=1/C8H10O2/c1-9-7-5-3-4-6-8(7)10-2/h3-6H,1-2H3 |
| InChIKey | ABDKAPXRBAPSQN-UHFFFAOYSA-N |
1,2-Dimethoxybenzene - Physico-chemical Properties
| Molecular Formula | C8H10O2 |
| Molar Mass | 138.16 |
| Density | 1.084g/mLat 25°C(lit.) |
| Melting Point | 15°C(lit.) |
| Boling Point | 206-207°C(lit.) |
| Flash Point | 189°F |
| JECFA Number | 1248 |
| Water Solubility | Soluble in alcohol, diethyl ether, acetone, and methanol. Slightly soluble in water. |
| Solubility | 6.69g/l insoluble |
| Vapor Presure | 0.63 hPa (25 °C) |
| Appearance | Powder |
| Color | White to cream |
| Merck | 14,9956 |
| BRN | 1364621 |
| Storage Condition | Store below +30°C. |
| Refractive Index | n20/D 1.533(lit.) |
| Physical and Chemical Properties | Density 1.08 melting point 15°C boiling point 206-207°C refractive index 1.533-1.535 flash point 87°C |
| Use | It is used as an intermediate in organic synthesis, and used in the pharmaceutical industry to synthesize tetrahydropalmatine and isoboridine. It is also a reagent for the determination of lactic acid and glycerol in blood. |
1,2-Dimethoxybenzene - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S36 - Wear suitable protective clothing. S23 - Do not breathe vapour. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 1 |
| RTECS | CZ6475000 |
| TSCA | Yes |
| HS Code | 29093090 |
| Toxicity | LD50 in rats, mice (mg/kg): 1360, 2020 orally (Jenner) |
1,2-Dimethoxybenzene - Reference Information
| FEMA | 3799 | 1,2-DIMETHOXYBENZENE |
| freezing point | 21.0 to 23.0 ℃ |
| LogP | 1.75-2.22 at 25℃ |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Application | 1, 2-phenyldimethyl ether (1, 2-dimethoxybenzene) is the fungicide dimethomorph, intermediates of flumorph. Used as an intermediate in organic synthesis, in the pharmaceutical industry, for the synthesis of tetrahydropalmatine, verapamil and so on. This product is also a commonly used reagent for the determination of lactic acid and glycerol in blood. 1, 2-phenyldimethyl ether (1, 2-dimethoxybenzene) is an intermediate of the bactericides dimethomorph and flumorph. It is used as an intermediate in organic synthesis, and used in the pharmaceutical industry to synthesize tetrahydropalmatine, verapamil, etc. This product is also a reagent for the determination of lactic acid and glycerol in blood. It is used as an intermediate in organic synthesis, and used in the pharmaceutical industry to synthesize tetrahydropalmatine and isoboridine. It is also a reagent for the determination of lactic acid and glycerol in blood |
| production method | 1. Derived from the methylation of guaiacol or catechol. 2. Purification method: the main impurities are catechol, peroxide and aldehyde. Catechol can be removed by washing with water. The aldehyde was removed by precipitation with P-nitrophenylhydrazine. O-dimethoxybenzene can also be refined by recrystallization from petroleum ether. 3. Crystals were obtained from petroleum ether. derived from methylated guaiacol or catechol. The preparation method is to mix catechol with sodium hydroxide, then add dimethyl sulfate under stirring, carry out alkyl reaction at a temperature of 30 ° C., and then separate, wash and distilled to obtain a finished product. It is also possible to use catechol to react with 40% sodium hydroxide to form sodium salt, and then react with methyl chloride under a certain pressure to obtain the finished product. |
| category | flammable liquid |
| toxicity grade | poisoning |
| Acute toxicity | oral-rat LD50: 890 mg/kg; Oral-mouse LD50: 700 mg/kg |
| flammability hazard characteristics | flammability; Combustion stimulus smoke |
| storage and transportation characteristics | warehouse ventilation and low temperature drying |
| extinguishing agent | dry powder, foam, sand, water |
Last Update：2024-04-09 21:11:58
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