1,5-Diaminopentane
1,5-Diaminopentane
CAS: 462-94-2
Molecular Formula: C7H16N2O6
1,5-Diaminopentane - Names and Identifiers
| Name | 1,5-Diaminopentane |
| Synonyms | Cadaverin Cadaverine H2N(CH2)5NH2 animalconiine Animal coniine 1,5-Pentanediamine 1,5-Diaminopentane 1,4-Pentanediamine Pentane-1,5-diamine 5,5'-PENTANEDIAMINE pentamethylenediamine propane-1,3-diamine 2,3-dihydroxybutanedioate (salt) |
| CAS | 462-94-2 |
| EINECS | 207-329-0 |
| InChI | InChI=1/C4H6O6.C3H10N2/c5-1(3(7)8)2(6)4(9)10;4-2-1-3-5/h1-2,5-6H,(H,7,8)(H,9,10);1-5H2 |
1,5-Diaminopentane - Physico-chemical Properties
| Molecular Formula | C7H16N2O6 |
| Molar Mass | 224.212 |
| Density | 0.873 g/mL at 25 °C(lit.) |
| Melting Point | 14-16℃ |
| Boling Point | 399.3°C at 760 mmHg |
| Flash Point | 209.4°C |
| Water Solubility | soluble |
| Vapor Presure | 4.93E-08mmHg at 25°C |
| Refractive Index | n20/D 1.458(lit.) |
| Physical and Chemical Properties | Chemical properties slurry liquid. Boiling point 178-180 ℃,78-80 ℃(1.6kPa). The relative density is 0.873(25/4 ℃) and the refractive index is 1.463. Soluble in water, ethanol, insoluble in ether, deep freezing can solidify and crystallize, but melt into liquid at room temperature. There is the odor of hexahydropyridine, which smokes in the air and can form dihydrate compounds. |
| Use | The application of 1, 5-diaminopentane can be produced by fermentation of genetically engineered Escherichia coli or Corynebacterium glutamicum. The resulting 1, 5-diaminopentane from the fermentation can be used for the production of novel biological polyamides. |
1,5-Diaminopentane - Risk and Safety
| Hazard Symbols | C - Corrosive |
| Risk Codes | R34 - Causes burns |
| Safety Description | S25 - Avoid contact with eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2735 |
1,5-Diaminopentane - Upstream Downstream Industry
| Raw Materials | L-Lysine Glutaronitrile |
| Downstream Products | 5-(Diethylamino)pentylamine Carbamic acid, N,N'-1,5-pentanediylbis-, C,C'-bis(1,1-dimethylethyl) ester N'-methylpentane-1,5-diamine N-Boc-cadaverine |
1,5-Diaminopentane - Nature
| solubility | 1 M HCl: soluble0.5g/10 mL, clear, colorless |
| acidity coefficient (pKa) | 10.05(at 25℃) |
| morphology | Liquid |
| color | Clear colorless to yellow |
| Odor | characteristic odor |
| water solubility | soluble |
| sensitivity | Air Sensitive & Hygroscopic |
| Merck | 14,1609 |
| BRN | 1697256 |
| stability | Stable. Incompatible with acid chlorides, acids, acid anhydrides, strong oxidizing agents, carbon dioxide. |
| InChIKey | VHRGRCVQAFMJIZ-UHFFFAOYSA-N |
| NIST chemical information | 1,5-Diaminopentane(462-94-2) |
| EPA chemical information | Cadaverine (462-94-2) |
Last Update：2024-04-10 22:29:15
1,5-Diaminopentane - Security information
| WGK Germany | 3 |
| RTECS number | SA0200000 |
| F | 10 |
| HazardClass | 8 |
| PackingGroup | III |
| customs code | 29212900 |
| toxic substance data | 462-94-2(Hazardous Substances Data) |
| Toxicity | dni-mus:ast 10 mmol/L AMOKAG 33,149,79 |
Last Update：2024-04-10 22:29:15
1,5-Diaminopentane - Uses and synthesis methods
introduction
1, 5-diaminopentane is a colorless and viscous fuming liquid with a special smell. It is used as an organic synthesis intermediate, epoxy resin curing agent, used in polymer preparation, and also used in biological research.
Preparation
1, 5-diaminopentane can be obtained by decarboxylation of lysine. Laboratory preparation can start from glutaronitrile: after boiling the absolute ethanol solution of glutaronitrile, add metal sodium at a faster speed, add water after the reaction, evaporate the ethanol, and use the remaining reactants Superheated steam distillation. The distillate is neutralized with dilute hydrochloric acid, evaporated to dry, the remainder is washed with cold anhydrous ethanol, and then a small amount of solid potassium hydroxide and water are used to decompose the hydrochloride salt, evaporate the water, and distill under reduced pressure to obtain 1, 5-Diaminopentane.
use
for organic synthesis.
production method
It is obtained by decarboxylation of lysine. Laboratory preparation can start from glutaronitrile: after boiling the absolute ethanol solution of glutaronitrile, add metal sodium at a faster speed, add water after the reaction, evaporate the ethanol, and use the remaining reactants Superheated steam distillation. The distillate is neutralized with dilute hydrochloric acid, evaporated to dry, and the remainder is washed with cold absolute ethanol, and then a small amount of solid potassium hydroxide and the hydrochloride obtained by water decomposition are used to evaporate the water and distill under reduced pressure to obtain cadaverine.
category
toxic substances
toxicity classification
Poisoning
acute toxicity
subcutaneous-rat LDL0: 1250 mg/kg; Oral-mouse LDL0:1600 mg/kg
flammability hazard characteristics
Open flame is combustible; high thermal decomposition releases nitrogen oxide gas
storage and transportation features
The warehouse is ventilated and dry at low temperature; it is stored separately from oxidants, acids, and food and chemical additives
fire extinguishing agent
dry powder, foam, carbon dioxide, sand.
Last Update：2024-04-09 18:58:34
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CAS: 462-94-2
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CAS: 462-94-2
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View History
Raw Materials for 1,5-Diaminopentane
Downstream Products for 1,5-Diaminopentane
5-(Diethylamino)pentylamine
Carbamic acid, N,N'-1,5-pentanediylbis-, C,C'-bis(1,1-dimethylethyl) ester
N'-methylpentane-1,5-diamine
N-Boc-cadaverine
Carbamic acid, N,N'-1,5-pentanediylbis-, C,C'-bis(1,1-dimethylethyl) ester
N'-methylpentane-1,5-diamine
N-Boc-cadaverine