Name | 1,1-dimethylguanidinium sulphate (2:1) |
Synonyms | Metformin Impurity 10 Sulfate 1,1-DIMETHYLGUANIDINE SULFATE N,N-DIMETHYLGUANIDINE SULFATE 1,1-DIMETHYL GUANIDINIUM SULFATE 1,1-DIMETHYLGUANIDINE HEMISULFATE SALT |
CAS | 598-65-2 |
EINECS | 209-946-0 |
InChI | InChI=1/C3H9N3/c1-6(2)3(4)5/h1-2H3,(H3,4,5)/p+1 |
Molecular Formula | C3H11N3O4S |
Molar Mass | 185.2 |
Melting Point | 300°C (dec.)(lit.) |
Boling Point | 104.7°C at 760 mmHg |
Flash Point | 17.1°C |
Vapor Presure | 30.4mmHg at 25°C |
Appearance | Powder |
Color | White to off-white |
BRN | 3916505 |
Storage Condition | Inert atmosphere,Room Temperature |
MDL | MFCD00013131 |
Physical and Chemical Properties | This product is a white powder solid, m.p.285 ~ 288 ℃, soluble in water, insoluble in organic solvents, when the melting point of decomposition. |
Hazard Symbols | Xi - Irritant |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
WGK Germany | 3 |
FLUKA BRAND F CODES | 3-10 |
HS Code | 29252900 |
EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
Use | 1, 1-dimethylguanidine sulfate is an intermediate of the fungicide dimethiol and the insecticide anisomarb. N,N-dimethylguanidine sulfate is an intermediate for the synthesis of pesticide pirimicarb. |
production method | N,N-dimethylguanidine sulfate is synthesized from lime nitrogen. CaCN2 H2O → NH2CN Ca(OH)2: add a certain amount of clear water in the reaction vessel in advance, and add lime nitrogen in batches under stirring, after stirring for 30~45min, the filter residue was quickly filtered, washed with clean water, and dried, and the filter residue was sent to the three wastes for treatment. The filtrate obtained above is driven into another decalcification kettle, and concentrated sulfuric acid is added dropwise for decalcification under stirring. When the pH value reaches 2~3, the filtrate can be filtered under stirring, and the filter residue is washed with clear water for 2 times, the residue was discarded. Put the decalcified cyanamide solution into a salt kettle, add 40% dimethylamine aqueous solution under stirring, then slowly warm up and reflux, dehydrate under reduced pressure after 4H, when a certain amount of water is collected, reaction Kettle crystallization, can stop heating, cooling to 0~5 ℃, cooling 1.5~2h after centrifugal filtration, N,N-dimethylguanidine sulfate, Dry for later use. N,N-diguanidine sulfate is also prepared in urea or from thiourea. The preparation method is to disperse S-methylisothiourea sulfate in cold water, slowly add 33% dimethylamine aqueous solution and stir constantly, after the reaction is complete, the solution is concentrated under reduced pressure, until there is crystallization, it is cooled to 0 ° C. And filtered to obtain crystals, and the mother liquor is concentrated to obtain crystals. The crystals are combined, washed with methanol and dried to obtain a finished product. In addition, it is also possible to react cyanamide with dimethylamine to Form 1, 1-dimethylguanidine sulfate. The reaction scheme is shown in figure: |