1,2-Bis-(hydroxyMethyl)-4-fluoro-benzene (AFIND01) 2-(RS)-Acetyl-5-fluoro-indane (AFIND03)
[5-fluoro-2-(hydroxymethyl)phenyl]methanol
CAS: 62558-08-1
Molecular Formula: C8H9FO2
1,2-Bis-(hydroxyMethyl)-4-fluoro-benzene (AFIND01) 2-(RS)-Acetyl-5-fluoro-indane (AFIND03) - Names and Identifiers
1,2-Bis-(hydroxyMethyl)-4-fluoro-benzene (AFIND01) 2-(RS)-Acetyl-5-fluoro-indane (AFIND03) - Physico-chemical Properties
| Molecular Formula | C8H9FO2 |
| Molar Mass | 156.15 |
| Density | 1.287±0.06 g/cm3(Predicted) |
| Boling Point | 288.6±30.0 °C(Predicted) |
| pKa | 13.99±0.10(Predicted) |
1,2-Bis-(hydroxyMethyl)-4-fluoro-benzene (AFIND01) 2-(RS)-Acetyl-5-fluoro-indane (AFIND03) - Upstream Downstream Industry
| Downstream Products | 6-Fluoro-3H-isobenzofuran-1-one |
1,2-Bis-(hydroxyMethyl)-4-fluoro-benzene (AFIND01) 2-(RS)-Acetyl-5-fluoro-indane (AFIND03) - Introduction
[5-fluoro-2-(hydroxymethyl)phenyl]methanol is an organic compound with the chemical formula C8H8F(OH), which is an alcohol compound containing a hydroxyl group on a benzene ring with a fluorine atom.
The following are the properties of [5-fluoro-2-(hydroxymethyl)phenyl]methanol:
-Appearance: White solid
-Melting point: About 60-62 ° C
-Boiling point: About 243 ° C
-Solubility: Solubility in water is small, and it has better solubility in organic solvents such as ethanol and dichloromethane.
[5-fluoro-2-(hydroxymethyl)phenyl]methanol has a wide range of applications in the field of medicinal chemistry and organic synthesis. It can be used as a raw material for the synthesis of drugs, pharmaceutical intermediates and chemical reagents. It can also be used as a source of fluorine atoms in organic synthesis, through which fluorine atoms can be introduced into organic molecules, thereby changing the properties of compounds.
Regarding the preparation method, a common method is to prepare [5-fluoro-2-(hydroxymethyl)phenyl]methanol by electrophilic substitution reaction of nitrobenzene. First, nitrobenzene is reacted with an electrophilic fluorinating reagent such as potassium tetrafluoroborate to give 4-fluoronitrobenzene. The 4-fluoronitrobenzene is then reduced to 4-fluoraminobenzene. Finally, 4-fluoraminobenzene is converted to [5-fluoro-2-(hydroxymethyl)phenyl]methanol by a reduction reaction or a hydrolysis reaction.
About Safety Information,[5-fluoro-2-(hydroxymethyl)phenyl]methanol has certain toxicity, and the following safety operation measures should be followed: Wear appropriate protective equipment, such as laboratory clothes and gloves; avoid contact with skin, eyes and respiratory tract; Maintain good ventilation during operation; Keep away from open flame and high temperature. Before use, please carefully read and follow the relevant safety instructions and operating instructions.
The following are the properties of [5-fluoro-2-(hydroxymethyl)phenyl]methanol:
-Appearance: White solid
-Melting point: About 60-62 ° C
-Boiling point: About 243 ° C
-Solubility: Solubility in water is small, and it has better solubility in organic solvents such as ethanol and dichloromethane.
[5-fluoro-2-(hydroxymethyl)phenyl]methanol has a wide range of applications in the field of medicinal chemistry and organic synthesis. It can be used as a raw material for the synthesis of drugs, pharmaceutical intermediates and chemical reagents. It can also be used as a source of fluorine atoms in organic synthesis, through which fluorine atoms can be introduced into organic molecules, thereby changing the properties of compounds.
Regarding the preparation method, a common method is to prepare [5-fluoro-2-(hydroxymethyl)phenyl]methanol by electrophilic substitution reaction of nitrobenzene. First, nitrobenzene is reacted with an electrophilic fluorinating reagent such as potassium tetrafluoroborate to give 4-fluoronitrobenzene. The 4-fluoronitrobenzene is then reduced to 4-fluoraminobenzene. Finally, 4-fluoraminobenzene is converted to [5-fluoro-2-(hydroxymethyl)phenyl]methanol by a reduction reaction or a hydrolysis reaction.
About Safety Information,[5-fluoro-2-(hydroxymethyl)phenyl]methanol has certain toxicity, and the following safety operation measures should be followed: Wear appropriate protective equipment, such as laboratory clothes and gloves; avoid contact with skin, eyes and respiratory tract; Maintain good ventilation during operation; Keep away from open flame and high temperature. Before use, please carefully read and follow the relevant safety instructions and operating instructions.
Last Update：2024-04-09 21:49:45
Supplier List
Product Name: [5-fluoro-2-(hydroxymethyl)phenyl]methanol Visit Supplier Webpage Request for quotation
CAS: 62558-08-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 62558-08-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: [5-fluoro-2-(hydroxymethyl)phenyl]methanol Visit Supplier Webpage Request for quotation
CAS: 62558-08-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 62558-08-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History
Downstream Products for 1,2-Bis-(hydroxyMethyl)-4-fluoro-benzene (AFIND01) 2-(RS)-Acetyl-5-fluoro-indane (AFIND03)