1,2-Pyrrolidinedicarboxylic acid, 1-benzyl ester, DL-(8CI) - Names and Identifiers
Name | 1,2-Pyrrolidinedicarboxylicacid, 1-(phenylmethyl) ester
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Synonyms | NSC 29728 Z-DL-PRO-OH Z-DL-PROLINE N-Cbz-DL-proline N-Carbobenzoxyproline N-Benzyloxycarbonyl-DL-proline Proline,N-(benzyloxy)carbonyl- 1-Cbz-pyrrolidine-2-carboxylic acid PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-BENZYL ESTER 1-(Benzyloxycarbonyl)pyrrolidine-2-carboxylicacid 1-[(benzyloxy)carbonyl]pyrrolicine-2-carboxylic acid 1-[(Benzyloxy)carbonyl]pyrrolidine-2-carboxylic acid 1,2-Pyrrolidinedicarboxylicacid, 1-(phenylmethyl) ester 1,2-Pyrrolidinedicarboxylic acid, 1-benzyl ester, DL-(8CI) 1,2-Pyrrolidinedicarboxylicacid, 1-(phenylmethyl) ester, (?à)-
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CAS | 5618-96-2
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1,2-Pyrrolidinedicarboxylic acid, 1-benzyl ester, DL-(8CI) - Physico-chemical Properties
Molecular Formula | C13H15NO4
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Molar Mass | 249.26 |
Density | 1.309±0.06 g/cm3(Predicted) |
Melting Point | 101-102 °C(Solv: ethyl ether (60-29-7); ligroine (8032-32-4)) |
Boling Point | 432.3±45.0 °C(Predicted) |
Flash Point | 215.3 °C |
pKa | 3.99±0.20(Predicted) |
Storage Condition | Sealed in dry,2-8°C |
Use | This product is for scientific research only and shall not be used for other purposes. |
1,2-Pyrrolidinedicarboxylic acid, 1-benzyl ester, DL-(8CI) - Introduction
1, 1-(phenylmethyl) ester(1, 1-, 1-(phenylmethyl) ester) is an organic compound. Its structure contains a DL-proline molecule and a benzyl ester group.
1, 1-(phenylmethyl) ester is a white crystalline solid with good solubility. It has the characteristics of good stability and high melting point.
1, 1-(phenylmethyl) ester has a wide range of applications in organic synthesis. It is often used as a reagent for protecting an amino group and can be used as a temporary protecting group in an amino protection reaction. In the synthesis of peptides and proteins, by introducing a N-Cbz group on the amino group, it is possible to avoid further reactions and interference from the amino group to be protected, and to easily remove the protecting group when necessary.
The preparation of 1, 1-(phenylmethyl) ester usually uses a multi-step synthesis method. A common preparation method is to react DL-proline with benzyl alcohol to give 1, -1-(phenylmethyl) ester.
Regarding safety information, the exact toxicity and harmfulness of 1, 1-(phenylmethyl) ester have not been fully studied. Use should follow laboratory safety procedures, prevent contact with skin and eyes, avoid inhalation or ingestion. It is recommended to operate under suitable ventilation conditions and use appropriate personal protective equipment. If exposed or inhaled, seek medical attention immediately and bring information about the compound to the hospital.
Last Update:2024-04-09 20:02:46