1,5-Methano-8H-pyrido(1,2-a)(1,5)diazocin-8-one, 1,2,3,4,5,6-hexahydro-
Cytisine
CAS: 485-35-8
Molecular Formula: C11H14N2O
1,5-Methano-8H-pyrido(1,2-a)(1,5)diazocin-8-one, 1,2,3,4,5,6-hexahydro- - Names and Identifiers
1,5-Methano-8H-pyrido(1,2-a)(1,5)diazocin-8-one, 1,2,3,4,5,6-hexahydro- - Physico-chemical Properties
| Molecular Formula | C11H14N2O |
| Molar Mass | 190.24 |
| Density | 1.0815 (rough estimate) |
| Melting Point | 154-156 °C (lit.) |
| Boling Point | 218 °C/2 mmHg (lit.) |
| Specific Rotation(α) | D17 -120° |
| Flash Point | 203.6°C |
| Water Solubility | 439g/L(16 ºC) |
| Solubility | Easily soluble in pyridine, acetone, ethanol, methanol, slightly soluble in chloroform, benzene, almost insoluble in petroleum ether and water. |
| Vapor Presure | 4.95E-07mmHg at 25°C |
| Appearance | Oblique prism white to yellow powder |
| Color | light yellow |
| Merck | 14,2789 |
| pKa | 6.11, 13.08(at 25℃) |
| Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
| Refractive Index | 1.5700 (estimate) |
| MDL | MFCD00136048 |
| Physical and Chemical Properties | Melting point 154-156°C(lit.) boiling point 218 ° C 2mm Hg(lit.) form powder color light yellow Merck 13,2818 |
1,5-Methano-8H-pyrido(1,2-a)(1,5)diazocin-8-one, 1,2,3,4,5,6-hexahydro- - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R25 - Toxic if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | HA4025000 |
| HS Code | 29399990 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 in mice (mg/kg): 1.73 i.v.; 9.4 i.p.; 101 orally (Barlow, McLeod) |
1,5-Methano-8H-pyrido(1,2-a)(1,5)diazocin-8-one, 1,2,3,4,5,6-hexahydro- - Reference
| Reference Show more | 1. Wu Yuhang, Han Zhong, Bao Ma Jiaze, etc. Study on the interaction between cytisine and bovine serum albumin by synchronous fluorescence spectroscopy combined with molecular docking [J]. Spectroscopy and spectral analysis 2016 36(003):765-769. 2. Zhao Shiyu, pen Xueyan, Yang pingyou, Kuang haixue, Wang Qiuhong, Lu shaowai. Analysis of active components in the anti-rheumatoid arthritis active fraction of Paeonia lutea based on HDAC3/8 molecular interaction technology [J]. Chinese herbal medicine, 2020,51(08):2117-2124. 3. Zhang Jing, Sun Xin. Physical and chemical properties of soybean milk fermented by Lactobacillus plantarum YS1 isolated from natural fermented yak yogurt [J]. Science and technology innovation and application, 2020, No.307(15):41-42. 4. Shi Xiaoying talked about Wen Pan, Li-Jun Song, etc. HPLC-MS detection of total alkaloids of Sophora alopecuroides double-coated pellets into the blood components [J]. Journal of Liaoning University of Traditional Chinese Medicine 2019 021(004):65-69. 5. [IF = 4.411] Simona S. Ghanem et al."Natural Alkaloid compositions as Inhibitors for Alpha-Synuclein Seeded Fibril Formation and Toxicity." Molecules. 2021 Jan;26(12):3736 |
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