1,6-O,O-Diacetylbritannilactone

1,6-O,O-Diacetylbritannilactone - Names and Identifiers

Name	1,6-O,O-diacetylbritannilactone
Synonyms	1,6-O,O-diacetylbritannilactone
CAS	151513-70-1

1,6-O,O-Diacetylbritannilactone - Physico-chemical Properties

Molecular Formula	C46H43N9O13S2
Molar Mass	994.01612
Melting Point	83-84 °C
Boling Point	485.5±45.0 °C
Specific Rotation(α)	(c, 0.171 in CHCl3)+37.5
Solubility	Soluble in methanol, ethanol, DMSO and other organic solvents
Appearance	White crystalline powder
Storage Condition	2-8℃

1,6-O,O-Diacetylbritannilactone - Reference Information

effect

diacetyl big flower Inula lactone is a natural product, which can reverse the multidrug resistance of tumor cells, it can be used as a reversal agent of tumor multidrug resistance; Diacetyl large flower Inula lactone also has the effect of increasing the sensitivity of tumor multidrug resistant cells to antitumor drugs, and can be used as a chemosensitizer.

preparation

the extraction method of sesquiterpene compounds including diacetyl big Inula lactone is as follows: take the dried heads of circumscribed flowers of traditional Chinese medicine and carry out the treatment according to the following steps: reflux extraction with ethanol of 6-10 times volume of the weight of the medicinal material, and concentrate under reduced pressure to obtain ethanol extract; Suspend the ethanol extract with water, extraction with petroleum ether, ethyl acetate, n-butanol, respectively, to obtain petroleum ether extract, ethyl acetate extract, n-butanol extract; The ethyl acetate extract, silica gel column chromatography, respectively, with petroleum ether-ethyl acetate, ethyl acetate, ethyl acetate-methanol gradient elution, TLC combining similar components, the resulting components were purified by preparative gel permeation chromatography GPC, gel (ToyopearlHW-40) column, semi-preparative HPLC to obtain sesquiterpene lactone compounds.

Last Update：2024-04-09 02:00:12