1-(2-Pyridyl)-1-propanone - Names and Identifiers
1-(2-Pyridyl)-1-propanone - Physico-chemical Properties
Molecular Formula | C8H9NO
|
Molar Mass | 135.16 |
Density | 1.034±0.06 g/cm3(Predicted) |
Melting Point | 206-207 °C |
Boling Point | 95-100 °C(Press: 15 Torr) |
pKa | 3.02±0.10(Predicted) |
Storage Condition | Inert atmosphere,Room Temperature |
Physical and Chemical Properties | NIST Chemical Information 1-Propanone, 1-(2-pyridinyl)-(3238-55-9) |
1-(2-Pyridyl)-1-propanone - Risk and Safety
Hazard Symbols | Xn - Harmful
|
Risk Codes | R22 - Harmful if swallowed
R36 - Irritating to the eyes
|
Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
|
Hazard Class | IRRITANT |
1-(2-Pyridyl)-1-propanone - Upstream Downstream Industry
1-(2-Pyridyl)-1-propanone - Introduction
2-propionylpyriridine (2-propionylpyriridine) is an organic compound with the chemical formula C8H9NO. It is a colorless liquid with a special aroma. The following is a description of the nature, use, preparation and safety information of 2-propionylpyriridine:
Nature:
-Appearance: colorless liquid
-Molecular weight: 135.16g/mol
-Boiling point: 200-201 ° C
-Melting point:-57 to -56 ° C
-Density: 1.032 g/mL
-Refractive index: n20/D 1.53
-Solubility: Soluble in alcohol and ether solvents, insoluble in water.
Use:
-2-propionylpyriridine is an important organic synthesis reagent, which is widely used in the pharmaceutical, pesticide and spice industries.
-It can be used as an intermediate for the synthesis of other organic compounds, such as the insecticide indamidine and the hemostatic agent Gennandi.
-It can also be used to prepare biologically active complexes and ligands for medical and chemical research.
Method:
-The most commonly used preparation method is to obtain 2-propionylpyriridine by the reaction of pyridine and propionyl chloride. The reaction is generally carried out under an inert atmosphere, usually under basic conditions.
-The specific preparation method is as follows:
-Dissolve pyridine in anhydrous xylene or dichloromethane and add propionyl chloride.
-Stir the reaction at room temperature for a period of time, and then purify the product by distillation.
Safety Information:
-2-propionylpyrridine is an organic synthetic reagent, which is potentially dangerous. The following safety precautions should be paid attention to during use and storage:
-Need to operate in a well-ventilated place to avoid inhaling aerosols or touching the skin.
-Avoid contact with strong oxidants, which may cause violent reactions.
-Wear protective glasses, gloves and appropriate protective clothing when using.
-Storage should be separated from other chemicals, stored in a cool, dry place, away from fire and combustible materials.
Please note that 2-Propionylpyridine is a chemical substance, and its correct and safe use requires appropriate chemical laboratories and knowledge. Please ensure that the correct chemical laboratory safety procedures are followed when operating.
Last Update:2024-04-09 19:05:55