1-(3-Methoxyphenyl)piperazine

1-(3-Methoxyphenyl)piperazine - Names and Identifiers

Name	1-(3-Methoxyphenyl)piperazine
Synonyms	AKOS BBS-00003611 RARECHEM AH CK 0127 TIMTEC-BB SBB003619 Letermovir Intermediate 3 N-(3-Methoxyphenyl)piperazine 1-(3-METHOXYPHENYL)PIPERAZINE 1-(3-Methoxyphenyl)piperazine 1-(3-METHOXYLPHENYL) PIPERAZINE 1-(3-Methyoxyphenyl)-piperazine
CAS	16015-71-7
EINECS	240-154-8
InChI	InChI=1/C11H16N2O/c1-14-11-4-2-3-10(9-11)13-7-5-12-6-8-13/h2-4,9,12H,5-8H2,1H3

1-(3-Methoxyphenyl)piperazine - Physico-chemical Properties

Molecular Formula	C11H16N2O
Molar Mass	192.26
Density	1.114 g/mL at 25 °C (lit.)
Melting Point	201-204°C
Boling Point	150 °C/0.5 mmHg (lit.)
Flash Point	195°F
Vapor Presure	6.8E-05mmHg at 25°C
Appearance	Solid
Color	Colorless to Light yellow
pKa	8.98±0.10(Predicted)
Storage Condition	2-8℃
Refractive Index	n20/D 1.5815(lit.)
MDL	MFCD00040733

1-(3-Methoxyphenyl)piperazine - Risk and Safety

Risk Codes	34 - Causes burns
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S27 - Take off immediately all contaminated clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	UN 3267 8/PG 3
WGK Germany	3
HS Code	29349990
Hazard Note	Irritant
Hazard Class	8
Packing Group	III

1-(3-Methoxyphenyl)piperazine - Introduction

1-(3-Methoxyphenyl)piperazine, also known as 3-methoxyphenylpiperazine, is an organic compound. Its chemical formula is C11H14N2O, which contains a methoxy group and a piperazine ring. It is a white crystalline solid.

1-(3-Methoxyphenyl)piperazine has a wide range of applications in the field of medicine. It is an angiotensin antagonist used to treat high blood pressure and heart failure. It dilates blood vessels and lowers blood pressure by blocking the action of the vasoconstrictor angiotensin. In addition, it can also be used to treat heart disease, kidney disease and other related diseases.

The preparation method of 1-(3-Methoxyphenyl)piperazine can be obtained by the reaction of styrene, 3-methoxybenzaldehyde and piperazine. First, styrene and 3-methoxybenzaldehyde are reacted under appropriate conditions to produce methyl 3-methoxyphenylacrylate. This Ester is then subjected to a reductive conjugation reaction to give 1-(3-Methoxyphenyl)piperazine.

Regarding the safety information of this compound, it may have certain toxicity and irritation. In use should follow the correct method of operation, avoid contact with skin, eyes and mucous membranes. During storage and handling, attention should be paid to fire and explosion prevention measures, and avoid contact with oxidants and strong acids. Read the relevant safety technical instructions carefully before use and operate in accordance with appropriate protective measures. In case of accidental contact, rinse with water immediately and seek medical help.

Last Update：2024-04-09 21:54:55

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