Name | 1-(2-Hydroxyethyl)-2-Methylimidazole |
Synonyms | methimidol Methimidol 2-methyl-1h-imidazole-1-ethano 2-Methyl-1H-imidazole-1-ethanol 1H-Imidazole-1-ethanol, 2-methyl- 2-(2-Methyl-imidazol-1-YL)-ethanol 1-(-Hydroxyethyl)-2-methyl imidazole 2-(2-methyl-1H-imidazol-1-yl)ethanol 1-(2-Hydroxyethyl)-2-Methylimidazole 2-(2-methyl-1H-imidazol-1-yl)ethan-1-ol 1-(2-Hydroxyethyl)-2-methyl-1H-imidazole Metronidazole Impurity (2-(2-Methyl-1H-imidazol-1-yl)ethanol hydrochloride) |
CAS | 1615-15-2 |
InChI | InChI=1/C6H10N2O/c1-6-7-2-3-8(6)4-5-9/h2-3,9H,4-5H2,1H3 |
InChIKey | WBRXPJXONZZELM-UHFFFAOYSA-N |
Molecular Formula | C6H10N2O |
Molar Mass | 126.16 |
Density | 1.12±0.1 g/cm3(Predicted) |
Melting Point | 63-65 °C(Solv: ethyl acetate (141-78-6)) |
Boling Point | 130-133 °C(Press: 0.15-0.25 Torr) |
Flash Point | 134.3°C |
Vapor Presure | 0.000566mmHg at 25°C |
pKa | 14.66±0.10(Predicted) |
Storage Condition | 2-8°C |
Refractive Index | 1.541 |
Hazard Symbols | Xn - Harmful |
Risk Codes | R22 - Harmful if swallowed R41 - Risk of serious damage to eyes |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. |
WGK Germany | 3 |
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
use | the hydrochloride of this product is the anti-leptospira drug metazolol. |
Production method | 2-methylimidazole and ethylenyl carbonate are prepared by hydroxyethylation. 2-methylimidazole and ethylene carbonate were added to toluene, stirred and heated, and refluxed at 105-113 ℃ for 6 hours. Cooling at 65 ℃, standing in layers, the upper layer is toluene layer, and the lower layer is 1-(β-hydroxyethyl)-2-methylimidazole. 44.4% yield. |