1-(2,4-dichlorophenyl)cyclobutane-1-carbonitrile - Names and Identifiers
1-(2,4-dichlorophenyl)cyclobutane-1-carbonitrile - Physico-chemical Properties
1-(2,4-dichlorophenyl)cyclobutane-1-carbonitrile - Introduction
1-(2,4-dichlorophenyl)cyclobutanecarbonitrile is an organic compound with the chemical formula C11H8Cl2N. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
1-(2,4-dichlorophenyl)cyclobutanecarbonitrile is a crystalline solid with unique physical and chemical properties. It is solid at normal temperature and soluble in organic solvents such as ethanol, dimethylformamide and chloroform. It has a higher melting point and boiling point, and has a weak flammability.
Use:
1-(2,4-dichlorophenyl)cyclobutanecarbonitrile has a wide range of applications in organic synthesis. It is often used as an intermediate in the pharmaceutical industry for the synthesis of anti-cancer drugs, anti-tuberculosis drugs and pesticides. In addition, it can also be used to synthesize organic light-emitting diode (OLED) materials and other organic functional materials.
Method:
Generally, the preparation method of 1-(2,4-dichlorophenyl)cyclobutanecarbonitrile is to generate the desired product by reacting 2,4-dichlorobenzyl alcohol and cyclobutanecarbonyl chloride. First, 2,4-dichlorobenzyl alcohol is reacted with a base to produce sodium dichlorobenzoxide salt. This sodium salt is then reacted with cyclobutanecarbonyl chloride to give 1-(2,4-dichlorophenyl) cyclobutanecarbonyl chloride. Finally, the resulting acid chloride is reacted with ammonia gas to give 1-(2,4-dichlorophenyl)cyclobutanecarbonitrile.
Safety Information:
When dealing with 1-(2,4-dichlorophenyl)cyclobutanecarbonitrile, necessary safety measures need to be taken. The specific safety information should refer to the Material Safety Data Sheet (MSDS). This compound may be irritating and corrosive to the eyes and skin, so direct contact should be avoided during operation. In addition, it should be operated in a well-ventilated place to avoid inhaling its vapors. When waste is disposed of, it should be disposed of in accordance with the relevant regulations.
Last Update：2024-04-09 21:01:54