1-(2-(benzyloxy)ethyl)-4-(hydroxydiphenylmethyl)quinuclidin-1-ium bromide

Name	Umeclidinium bromide(API)
Synonyms	CS-1562 BROMIDE GSK573719A GSK-573719A GSK 573719A Umeclinidium bromide Umeclidinium bromide(API) Umeclidinium bromide(GSK573719A) 1-(2-(benzyloxy)ethyl)-4-(hydroxydiphenylmethyl)quinuclidin-1-ium bromide 1-[2-(Benzyloxy)ethyl]-4-(hydroxydiphenylmethyl)-1-quinuclidinium Bromide DIPHENYL-[1-(2-PHENYLMETHOXYETHYL)-1-AZONIABICYCLO[2.2.2]OCTAN-4-YL]METHANOL
CAS	869113-09-7
EINECS	638-761-1

Molecular Formula	C29H34BrNO2
Molar Mass	508.48976
Melting Point	>231°C (dec.)
Solubility	DMSO (Slightly), Methanol (Slightly), Water (Slightly)
Appearance	Solid
Color	White to Off-White
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Stability	Hygroscopic

Last Update：2024-01-02 23:10:35

COPD drug	umeclidinium bromide was developed by GlaxoSmithKline (GSK), first approved for marketing by Health Canada on April 17, 2014, then approved by the European Medicines Agency (EMA) on April 28, it was later approved for marketing by the U. S. Food and Drug Administration (FDA) on 4/30/2014 and then approved by the Japanese medical and medical device administration (PMDA) on 3/26/2015. Marketed by GSK under the trade name Incruse Ellipta®, Incruse®And Encruse®. umeclidinium bromide is a long-acting, competitive and reversible muscarinic choline receptor antagonist (mAChRs) that maintains bronchodilation. The drug is indicated for the treatment of airflow obstruction in patients with chronic obstructive pulmonary disease (COPD). Incruse Ellipta®It is an inhalable powder containing 62.5 μg of umeclidinium bromide. The recommended dose is 62.5 μg per inhalation (1 inhalation), once daily.
mechanism of action	umeclidinium bromide is a long-acting choline receptor antagonist (LAMA) that relaxes bronchial smooth muscle. The kinetic selectivity for the M3 receptor is higher than for the M2 receptor, with slower dissociation with the M3 receptor than with m2. And has the effect of anti parasympathetic nerve, can inhibit the role of M3 receptor.
synthetic routes

Last Update：2024-04-09 20:45:29

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1-(2-(benzyloxy)ethyl)-4-(hydroxydiphenylmethyl)quinuclidin-1-ium bromide Request for Quotation