1-(3-chloro-5-fluorophenyl)cyclopropan-1-amine hydrochloride - Names and Identifiers
1-(3-chloro-5-fluorophenyl)cyclopropan-1-amine hydrochloride - Physico-chemical Properties
| Molecular Formula | C9H9ClFN
|
| Molar Mass | 185.63 |
1-(3-chloro-5-fluorophenyl)cyclopropan-1-amine hydrochloride - Introduction
1-(3-chloro-5-fluorophenyl)cyclopropan-1-amine is an organic compound containing a cyclopropane ring and an amino group in its chemical structure. The following is a description of its nature, use, preparation and safety information:
Nature:
1-(3-chloro-5-fluorophenyl)cyclopropan-1-amine is a white crystalline solid. It is soluble in water and ethanol at room temperature and insoluble in non-polar solvents. The compound is stable in the solid state, but decomposes thermally.
Use:
1-(3-chloro-5-fluorophenyl)cyclopropan-1-amine has antidepressant activity, so it may be used as an intermediate for antidepressants in the field of drug research. It may also be used in the synthesis of other organic compounds, for example for the synthesis of pesticides or other functional molecules.
Method:
The synthesis method of 1-(3-chloro-5-fluorophenyl)cyclopropan-1-amine can be carried out by reacting cyanobenzene or lithium benzene fluoride with 3-chloro-5-fluoronitrobenzene in cyclopropane. Nucleophilic substitution reaction, 1-(3-Chloro-5-fluorophenyl) Cyclopropane is obtained. Then, 1-(3-chloro-5-fluorophenyl) Cyclopropane is reacted with ammonia to form 1-(3-chloro-5-fluorophenyl) cyclopropane -1-Amine, the final reaction with hydrochloric acid gives the hydrochloride form.
Safety Information:
Since 1-(3-chloro-5-fluorophenyl)cyclopropan-1-amine hydrochloride is a chemical, relevant safety procedures should be followed during handling and storage. It may cause irritation or toxicity to the human body, so wear appropriate personal protective equipment such as glasses and gloves when using it. During handling, care should be taken to avoid inhaling, chewing or swallowing the compound. In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical help. Proper use and disposal of this compound in a safe operating environment is very important.
Last Update：2024-04-09 21:04:16