1-(4-TrifluoroMethylbenzyl)piperazine 2HCl

1-(4-TrifluoroMethylbenzyl)piperazine 2HCl - Names and Identifiers

Name	1-(4-(TRIFLUOROMETHYL)BENZYL)PIPERAZINE&
Synonyms	1-[4-(Trifluoromethyl)benzyl]piperazine N-[4-(Trifluoromethyl)benzyl]piperazine 1-(4-TrifluoroMethylbenzyl)piperazine 2HCl 1-[4-(trifluoromethyl)benzyl]piperazinediium 1-[[4-(trifluoromethyl)phenyl]methyl]piperazine Piperazine, 1-[[4-(trifluoromethyl)phenyl]methyl]- piperazine, 1-[[4-(trifluoromethyl)phenyl]methyl]-
CAS	107890-32-4
InChI	InChI=1/C12H15F3N2/c13-12(14,15)11-3-1-10(2-4-11)9-17-7-5-16-6-8-17/h1-4,16H,5-9H2/p+2

1-(4-TrifluoroMethylbenzyl)piperazine 2HCl - Physico-chemical Properties

Molecular Formula	C12H15F3N2
Molar Mass	244.26
Density	1.239g/mLat 25°C
Boling Point	88-89°C0.02mm Hg
Flash Point	>230°F
Vapor Presure	0.00305mmHg at 25°C
pKa	9.07±0.10(Predicted)
Storage Condition	Room Temprature
Refractive Index	n20/D 1.491
Physical and Chemical Properties	WGK Germany:2

1-(4-TrifluoroMethylbenzyl)piperazine 2HCl - Risk and Safety

Risk Codes	R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
UN IDs	UN 2811 6.1/PG 3
WGK Germany	2

1-(4-TrifluoroMethylbenzyl)piperazine 2HCl - Introduction

1-[4-(trifluoromethyl) benzyl] piperazine, chemical formula C14H13F3N2. It is an organic compound with the following common properties:

1. Properties: 1-[4-(trifluoromethyl) benzyl] piperazine is a white crystalline solid with high melting point and boiling point. It is stable at normal temperature and insoluble in water, but soluble in organic solvents such as ethanol and dimethylformamide.

2. use: this compound is widely used in the field of medicine. It has antipsychotic activity and is often used as an intermediate for antipsychotic drugs. In addition, it can also be used to synthesize other organic compounds, such as pesticides and dyes.

3. Preparation method: 1-[4-(trifluoromethyl) benzyl] piperazine is generally synthesized by organic synthesis method. A common method of preparation is to react phenylmagnesium bromide with N-(4-chlorobenzyl) ligand to give N-(4-benzyl) benzyl substituted phenylmagnesium bromide, followed by N-benzylation of this compound with trifluoromethylpiperazine to give the final product.

4. Safety information: 1-[4-(trifluoromethyl) benzyl] piperazine has certain toxicity, and care should be taken to avoid contact with skin and eyes. Wear appropriate protective gloves and glasses during use. At the same time, the compound should be kept tightly closed during storage and transportation, away from fire and oxidizing agents. If there is an accident, the corresponding emergency measures should be taken immediately, and the advice of professionals should be consulted.

Last Update：2024-04-09 21:11:58