1-(phenylmethoxycarbonylamino)-1-cyclopropanecarboxylic acid
1-(N-cbz-amino)cyclopropanecarboxylic*acid
CAS: 84677-06-5
Molecular Formula: C12H13NO4
1-(phenylmethoxycarbonylamino)-1-cyclopropanecarboxylic acid - Names and Identifiers
1-(phenylmethoxycarbonylamino)-1-cyclopropanecarboxylic acid - Physico-chemical Properties
| Molecular Formula | C12H13NO4 |
| Molar Mass | 235.24 |
| Density | 1.33±0.1 g/cm3(Predicted) |
| Melting Point | 157.0 to 161.0 °C |
| Boling Point | 449.0±34.0 °C(Predicted) |
| Flash Point | 225.4°C |
| Vapor Presure | 7.55E-09mmHg at 25°C |
| pKa | 4.02±0.20(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Refractive Index | 1.593 |
1-(phenylmethoxycarbonylamino)-1-cyclopropanecarboxylic acid - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
1-(phenylmethoxycarbonylamino)-1-cyclopropanecarboxylic acid - Introduction
1-(N-cbz-amino)cyclopropanecarboxylic * acid is an organic compound containing amino, cyclopropane and carboxyl groups in its chemical structure.
Nature:
1-(N-cbz-amino)cyclopropanecarboxylic * acid is a solid, usually white to yellow crystalline. It is insoluble in water at room temperature, but can be dissolved in some organic solvents, such as methanol, dimethylformamide and ether. Its melting point is about 220-230°C.
Use:
1-(N-cbz-amino)cyclopropanecarboxylic * acid is an important intermediate in organic synthesis. It can be used to synthesize various drugs, pesticides and bioactive molecules. The compound has high chemical stability and can be used as a protecting group (Cbz group) in many reactions to selectively protect the amino group. It has a wide range of applications in the synthesis, such as the synthesis of anti-tumor drugs, protein expression regulators and so on.
Preparation Method:
The preparation method of 1-(N-cbz-amino)cyclopropanecarboxylic * acid usually involves the protection of hydroxynitrile and the addition reaction of aminocyclopropane. One common method is to react an aminocyclopropane with an active formate to give 1-hydroxycyclopropane, which is then protected. A common protecting reagent is chloromethylformamide. Finally, the protecting group is removed by treatment with carbonic acid or sulfuryl chloride to give 1-(N-cbz-amino)cyclopropanecarboxylic * acid.
Safety Information:
1-(N-cbz-amino)cyclopropanecarboxylic * acid is generally considered non-toxic to humans under normal operating conditions. However, it may cause irritation to the eyes, skin and respiratory system. Therefore, during operation, care should be taken to avoid contact and use personal protective equipment, such as gloves and eye protection, if necessary. In addition, it should be operated in a well-ventilated place to avoid inhaling its dust or steam. If contact or inhalation occurs, rinse immediately with clean water and seek medical help as needed.
Nature:
1-(N-cbz-amino)cyclopropanecarboxylic * acid is a solid, usually white to yellow crystalline. It is insoluble in water at room temperature, but can be dissolved in some organic solvents, such as methanol, dimethylformamide and ether. Its melting point is about 220-230°C.
Use:
1-(N-cbz-amino)cyclopropanecarboxylic * acid is an important intermediate in organic synthesis. It can be used to synthesize various drugs, pesticides and bioactive molecules. The compound has high chemical stability and can be used as a protecting group (Cbz group) in many reactions to selectively protect the amino group. It has a wide range of applications in the synthesis, such as the synthesis of anti-tumor drugs, protein expression regulators and so on.
Preparation Method:
The preparation method of 1-(N-cbz-amino)cyclopropanecarboxylic * acid usually involves the protection of hydroxynitrile and the addition reaction of aminocyclopropane. One common method is to react an aminocyclopropane with an active formate to give 1-hydroxycyclopropane, which is then protected. A common protecting reagent is chloromethylformamide. Finally, the protecting group is removed by treatment with carbonic acid or sulfuryl chloride to give 1-(N-cbz-amino)cyclopropanecarboxylic * acid.
Safety Information:
1-(N-cbz-amino)cyclopropanecarboxylic * acid is generally considered non-toxic to humans under normal operating conditions. However, it may cause irritation to the eyes, skin and respiratory system. Therefore, during operation, care should be taken to avoid contact and use personal protective equipment, such as gloves and eye protection, if necessary. In addition, it should be operated in a well-ventilated place to avoid inhaling its dust or steam. If contact or inhalation occurs, rinse immediately with clean water and seek medical help as needed.
Last Update：2024-04-09 21:00:56
