1-(tert-butoxycarbonyl)-4-phenylpyrrolidine-3-carboxylic acid
(3S,4R)-1-(tert-butoxycarbonyl)-4-phenylpyrrolidine-3-carboxylic acid
CAS: 221142-28-5;884048-45-7
Molecular Formula: C16H21NO4
1-(tert-butoxycarbonyl)-4-phenylpyrrolidine-3-carboxylic acid - Names and Identifiers
1-(tert-butoxycarbonyl)-4-phenylpyrrolidine-3-carboxylic acid - Physico-chemical Properties
| Molecular Formula | C16H21NO4 |
| Molar Mass | 291.34 |
| Density | 1.196g/cm3 |
| Boling Point | 441.5°C at 760 mmHg |
| Flash Point | 220.8°C |
| Vapor Presure | 1.43E-08mmHg at 25°C |
| Storage Condition | 2-8°C |
| Refractive Index | 1.548 |
1-(tert-butoxycarbonyl)-4-phenylpyrrolidine-3-carboxylic acid - Risk and Safety
| HS Code | 29339900 |
1-(tert-butoxycarbonyl)-4-phenylpyrrolidine-3-carboxylic acid - Introduction
(3S,4R)-1-(tert-butoxycarbonyl)-acid ((3S,4R)-1-(tert-butoxycarbonyl)-acid) is an organic compound, its chemical formula is C17H21NO4.
Nature:
-Appearance: White crystalline solid
-Melting point: approximately in the range of 140-144 ° C
-Solubility: Soluble in common organic solvents, such as alcohols, ethers and chlorinated hydrocarbons
-Stability: relatively stable at room temperature
Use:
(3S,4R)-1-(tert-butoxycarbonyl)-acid is an important organic synthesis intermediate, often used in the synthesis of drugs, pesticides and other organic compounds. One common use of it is as a protecting group in peptide synthesis for the synthesis of specific structures and functions of compounds.
Method:
Preparation of (3S,4R)-1-(tert-butoxycarbonyl)-sulfuric acid is generally carried out by the following steps:
1. The reaction raw material 1: 4-phenylpyrrolidine-3-carbaldehyde reacts with the reaction raw material 2:N,N-dibenzamide to generate 4-phenylpyrrolidine-3-carboxylic acid dibenzyl ester.
2. Reaction raw material 3: p-toluenesulfonic acid and N-phenyl-N'-tert-butyl nitrile react to produce p-toluenesulfonic acid-N-phenyl-N'-tert-butyl nitrile.
3. Reaction raw material 4: P-toluenesulfonic acid-N-phenyl-N'-tert-butyl nitrile and 4-phenylpyrrolidine-3-carboxylic acid diphenyl methyl ester are synthesized, diphenylmethyl trans-N-(tert-butoxycarbonyl)-4-phenylpyrrolidine-3-carboxylate is produced.
4. Reaction raw material 5: Trans-N-(tert-butoxycarbonyl)-4-phenylpyrrolidine-3-carboxylic acid diphenyl methyl ester reacts with hydrochloric acid to generate (3S,4R)-1-(tert-butoxycarbonyl)-acid.
Safety Information:
(3S,4R)-1-(tert-butoxycarbonyl)-The acid is relatively safe for the human body under normal conditions of use. However, as a chemical, appropriate laboratory practices and personal protective measures should be followed. Avoid contact with eyes and skin, and avoid inhaling gas or swallowing during operation. If splashed on the eyes or skin, rinse immediately with water and seek medical help. Follow proper waste handling procedures when handling and storing.
Nature:
-Appearance: White crystalline solid
-Melting point: approximately in the range of 140-144 ° C
-Solubility: Soluble in common organic solvents, such as alcohols, ethers and chlorinated hydrocarbons
-Stability: relatively stable at room temperature
Use:
(3S,4R)-1-(tert-butoxycarbonyl)-acid is an important organic synthesis intermediate, often used in the synthesis of drugs, pesticides and other organic compounds. One common use of it is as a protecting group in peptide synthesis for the synthesis of specific structures and functions of compounds.
Method:
Preparation of (3S,4R)-1-(tert-butoxycarbonyl)-sulfuric acid is generally carried out by the following steps:
1. The reaction raw material 1: 4-phenylpyrrolidine-3-carbaldehyde reacts with the reaction raw material 2:N,N-dibenzamide to generate 4-phenylpyrrolidine-3-carboxylic acid dibenzyl ester.
2. Reaction raw material 3: p-toluenesulfonic acid and N-phenyl-N'-tert-butyl nitrile react to produce p-toluenesulfonic acid-N-phenyl-N'-tert-butyl nitrile.
3. Reaction raw material 4: P-toluenesulfonic acid-N-phenyl-N'-tert-butyl nitrile and 4-phenylpyrrolidine-3-carboxylic acid diphenyl methyl ester are synthesized, diphenylmethyl trans-N-(tert-butoxycarbonyl)-4-phenylpyrrolidine-3-carboxylate is produced.
4. Reaction raw material 5: Trans-N-(tert-butoxycarbonyl)-4-phenylpyrrolidine-3-carboxylic acid diphenyl methyl ester reacts with hydrochloric acid to generate (3S,4R)-1-(tert-butoxycarbonyl)-acid.
Safety Information:
(3S,4R)-1-(tert-butoxycarbonyl)-The acid is relatively safe for the human body under normal conditions of use. However, as a chemical, appropriate laboratory practices and personal protective measures should be followed. Avoid contact with eyes and skin, and avoid inhaling gas or swallowing during operation. If splashed on the eyes or skin, rinse immediately with water and seek medical help. Follow proper waste handling procedures when handling and storing.
Last Update：2024-04-09 20:45:29
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Multiple Specifications
Product Name: (3S,4R)-1-(tert-butoxycarbonyl)-4-phenylpyrrolidine-3-carboxylic acid Visit Supplier Webpage Request for quotationCAS: 884048-45-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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