1-Benzofuran-3(2H)-one, Coumaran-3-one

Name	3-Coumaranone
Synonyms	3-Coumaranone 3-Oxocoumaran Benzofuran-3-one benzofuran-3(2H)-one 1-benzofuran-3(2H)-one 1-Benzofuran-3(2H)-one Benzo[b]furan-3(2H)-one 2,3-dihydro-1-benzofuran-2-one 3-Coumaranonebenzofuran-3(2H)-one 1-Benzofuran-3(2H)-one, Coumaran-3-one 1-Benzofuran-3(2H)-one, Coumaran-3-one, 2,3-Dihydro-3-oxo-1-benzofuran
CAS	7169-34-8
EINECS	640-279-1
InChI	InChI=1/C8H6O2/c9-7-5-10-8-4-2-1-3-6(7)8/h1-4H,5H2

Molecular Formula	C8H6O2
Molar Mass	134.13
Density	1.1603 (rough estimate)
Melting Point	101-103 °C
Boling Point	207.23°C (rough estimate)
Flash Point	118.944°C
Water Solubility	Slightly miscible with water.
Solubility	Chloroform (Slightly), DMSO (Slightly)
Vapor Presure	0.023mmHg at 25°C
Appearance	Crystallization
Color	Yellow to Dark Yellow
BRN	115296
Storage Condition	Keep in dark place,Sealed in dry,Store in freezer, under -20°C
Sensitive	Light Sensitive
Refractive Index	1.4800 (estimate)
MDL	MFCD00051810

Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
Safety Description	S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	3
FLUKA BRAND F CODES	4.5-9
HS Code	29329990
Hazard Note	Irritant

, 3-benzofuran ketone compounds have good physiological activity, and its derivatives have antibacterial, antiviral, antioxidant and other effects.

NIST chemical information	information provided by: webbook.nist.gov (external link)
Introduction
Application	3-benzofuran ketones are also important pharmaceutical and chemical intermediates, which can be widely used in the synthesis of pharmaceuticals, pesticides, new antioxidants and food additives. For this reason, it is of great practical significance and application value to develop a practical and efficient method for the synthesis of 3-benzofuranones.
preparation	under normal temperature and pressure, dissolve 0.2mmol of 2-ethynylphenol in 1ml of dichloromethane, to a solution of 2-ethynylphenol in methylene chloride, 0.01mmol of Mercury triflate and 0.24mmol of pyridine-N-oxide were added, the mixture was stirred at room temperature for 1 hour at a stirring rate of 600r/min, and 3-benzofuranone was reacted to form. 24.7mg of 3-benzofuranone was obtained by silica gel column chromatography, and the yield was 92.2%.

Last Update：2024-04-09 21:01:54

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