1-Boc-3-(aminomethyl)azetidine

1-Boc-3-(aminomethyl)azetidine - Names and Identifiers

Name	1-Boc-3-(aminomethyl)azetidine
Synonyms	1-Boc-aminoazetidine 1-Boc-3-(aminomethyl)azetidine 1-BOC-3-(AMINOMETHYL)AZETIDINE 1-Boc-3-(Aminomethyl)azetidine 3-AMINOMETHYL-1-N-BOC-AZETIDINE 1-N-BOC-3-AMINOMETHYL AZETIDINE 1-Boc-3-Aminomethylazetidine HCl tert-Butyl-3-(aminomethyl)azetidin-1-carboxylat TERT-BUTYL 3-(AMINOMETHYL)AZETIDINE-1-CARBOXYLATE tert-butyl 3-(aminomethyl)azetidine-1-carboxylate 3-AMINOMETHYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 2-Methyl-2-propanyl 3-(aminomethyl)-1-azetidinecarboxylate 1-Azetidinecarboxylic acid, 3-(aminomethyl)-, 1,1-dimethylethyl ester
CAS	325775-44-8
InChI	InChI=1/C9H18N2O2/c1-9(2,3)13-8(12)11-5-7(4-10)6-11/h7H,4-6,10H2,1-3H3
InChIKey	XSJPKMUFBHSIRA-UHFFFAOYSA-N

1-Boc-3-(aminomethyl)azetidine - Physico-chemical Properties

Molecular Formula	C9H18N2O2
Molar Mass	186.25
Density	1.0234 g/mL at 25 °C
Boling Point	260.6±13.0 °C(Predicted)
Flash Point	>110 °C
Vapor Presure	0.012mmHg at 25°C
Appearance	Colorless Liquid
pKa	9.97±0.29(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Sensitive	Air Sensitive
Refractive Index	1.4670
MDL	MFCD01861762

1-Boc-3-(aminomethyl)azetidine - Risk and Safety

Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R25 - Toxic if swallowed
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	2810
WGK Germany	1
Hazard Class	IRRITANT
Packing Group	Ⅲ

1-Boc-3-(aminomethyl)azetidine - Introduction

1-Boc-3-(aminomethyl)azetidine is an organic compound with the chemical formula C12H23NO3. It is a compound containing an aminomethyl group and an azetidine ring.

Nature:
1-Boc-3-(aminomethyl)azetidine is a solid with a white or white-like appearance. It is insoluble in water at normal temperature, but soluble in organic solvents such as alcohol, methanol and dimethyl sulfoxide.

Use:
1-Boc-3-(aminomethyl)azetidine is an important intermediate in organic synthesis. It is widely used for Amine protecting groups in organic synthesis. By introducing a Boc protecting group, the reactivity of the amine group can be protected and more selectivity can be provided in the synthesis.

Method:
1-Boc-3-(aminomethyl)azetidine can be prepared by reacting azetidine with tert-butoxycarbonyl chloride. First, azetidine is dissolved in an organic solvent, and then tert-butoxycarbonyl is slowly added to the reaction system. After the reaction, the product is purified by crystallization or column chromatography.

Safety Information:
1-Boc-3-(aminomethyl)azetidine is safe, but it is a chemical and should follow safe operating procedures and wear appropriate protective equipment when operating, such as gloves and goggles. At the same time, store it in a cool, dry and well-ventilated place, away from fire and combustibles. When using or disposing, comply with the relevant local regulations and handle in accordance with the correct method. In the event of an accident or discomfort, the application should be stopped immediately and medical assistance should be sought.

Last Update：2024-04-10 22:29:15