1-Deoxygalactonojirimycin Hydrochloride
1-Deoxygalactonojirimycin Hydrochloride
CAS: 75172-81-5
Molecular Formula: C6H14ClNO4
1-Deoxygalactonojirimycin Hydrochloride - Names and Identifiers
1-Deoxygalactonojirimycin Hydrochloride - Physico-chemical Properties
| Molecular Formula | C6H14ClNO4 |
| Molar Mass | 199.63 |
| Melting Point | 260 |
| Solubility | Methanol (Slightly), Water (Slightly) |
| Appearance | White crystalline solid |
| Color | White to Brown |
| Storage Condition | 2-8°C |
| In vitro study | Both IC 50 and K i values of Migalastat (GR181413A) hydrochloride toward human lysosomal a-Gal A are 0.04 μM. |
| In vivo study | Fabry disease is an X-linked recessive disorder caused by the deficient activity of α-galactosidase A. α-Gal A activity in heart, kidney, spleen, and liver is increased dose- and time-dependently in transgenic mice that express human mutant alpha-Gal A with Migalastat (GR181413A) hydrochloride treatment. The half-life of DGJ is less than 1 day in all major issues and that of the enzyme synthesized during the DGJ treatment period is approximately 4 days. Oral administration of Migalastat (GR181413A) hydrochloride reduces tissue GL-3 in fabry transgenic mice, and in urine and kidneys of some FD patients. Oral administration of Migalastat (GR181413A) hydrochloride to transgenic mice reduces elevated lyso-Gb3 levels up to 64%, 59%, and 81% in kidney, heart, and skin, respectively, generally equal to or greater than observed for GL-3. |
1-Deoxygalactonojirimycin Hydrochloride - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 29333990 |
| Hazard Note | Irritant |
1-Deoxygalactonojirimycin Hydrochloride - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 5.009 ml | 25.046 ml | 50.093 ml |
| 5 mM | 1.002 ml | 5.009 ml | 10.019 ml |
| 10 mM | 0.501 ml | 2.505 ml | 5.009 ml |
| 5 mM | 0.1 ml | 0.501 ml | 1.002 ml |
Last Update：2024-01-02 23:10:35
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Spot supply
Product Name: 1-Deoxygalactonojirimycin Hydrochloride Visit Supplier Webpage Request for quotationCAS: 75172-81-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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