1-Methyl-1H-pyrazole-3-boronic acid pinacol ester
1-Methyl-1H-pyrazole-5-boronic acid pinacol ester
CAS: 847818-74-0
Molecular Formula: C10H17BN2O2
1-Methyl-1H-pyrazole-3-boronic acid pinacol ester - Names and Identifiers
1-Methyl-1H-pyrazole-3-boronic acid pinacol ester - Physico-chemical Properties
| Molecular Formula | C10H17BN2O2 |
| Molar Mass | 208.07 |
| Density | 1.05±0.1 g/cm3(Predicted) |
| Melting Point | 67-71 °C |
| Boling Point | 308.3±15.0 °C(Predicted) |
| Flash Point | 140.3°C |
| Water Solubility | Slightly soluble in water. |
| Vapor Presure | 0.00125mmHg at 25°C |
| Appearance | White crystal |
| Color | white |
| pKa | 1.94±0.10(Predicted) |
| Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
| Refractive Index | 1.505 |
| MDL | MFCD05861380 |
1-Methyl-1H-pyrazole-3-boronic acid pinacol ester - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| TSCA | No |
| HS Code | 29349990 |
| Hazard Class | IRRITANT |
1-Methyl-1H-pyrazole-3-boronic acid pinacol ester - Reference Information
| introduction | 1-methyl -1H-pyrazole -5-borate pinacol ester has a melting point of 67 to 71 degrees, a density of 1.1, and a brown-gray solid powder appearance under normal temperature and pressure. It has good solubility in common organic solvents such as ethyl acetate, dichloromethane and dimethyl sulfoxide, almost insoluble in water, and can be used as an intermediate in organic synthesis. |
| Use | 1-methyl-1H-pyrazole -5-borate pinacol ester is a common organic synthesis intermediate. Pyrazole units are commonly found in biologically active molecules, so this compound is often used in the modification and derivatization of drug molecules and biologically active molecules. The borate ester in this structure can undergo a series of boron transformations, including the Suzuki coupling reaction to convert boron into aryl groups; also to obtain hydroxyl compounds through the oxidation of hydrogen peroxide; in addition, it can also pass other The coupling conditions convert carbon-boron bonds into carbon-oxygen bonds, carbon-nitrogen bonds and carbon-halogen bonds. |
| synthesis method | for the synthesis of 1-methyl-1H-pyrazole -5-borate pinacol ester, the conventional synthesis method is to start from 1-methyl pyrazole, by pulling out the hydrogen on the carbon next to the nitrogen atom with methyl group under the action of a strong base, add trimethyl borate or triisopropyl borate to hydrolyze to obtain the corresponding boric acid compound. Boric acid can be protected by pinacol to obtain the target product. |
Last Update：2024-04-09 15:16:36
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