1-Methyl-4-(3-pyrrolidinyl)-piperazine Trihydrochloride - Names and Identifiers
1-Methyl-4-(3-pyrrolidinyl)-piperazine Trihydrochloride - Physico-chemical Properties
1-Methyl-4-(3-pyrrolidinyl)-piperazine Trihydrochloride - Introduction
1-Methyl-4-(3-pyrrolidinyl) piperazine dihydrochloride, often abbreviated as MPTP(1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride), is an organic compound. The following is a description of its nature, use, preparation and safety information:
Nature:
1-methyl -4-(3-pyrrolidinyl) piperazine dihydrochloride is white or white crystalline powder, slightly soluble in water, soluble in alcohol and ether solvents. It has weak acidity.
Use:
1-Methyl -4-(3-pyrrolidinyl) piperazine dihydrochloride is an alkaloid with neurotoxicity. It is widely used in model preparation for the study of Parkinson's disease. By injection or gavage in animals, MPTP can cause Parkinson-like symptoms, and researchers can use this property to study the mechanism of the disease and find treatments.
Preparation Method:
There are two main methods for preparing 1-methyl -4-(3-pyrrolidinyl) piperazine dihydrochloride. One of them is the reaction of 1-methyl -4-(2-pyridyl) piperazine with pyrrolidinol, and the hydrochloride is prepared by acid-base neutralization. The other is the reaction of phenylacetonitrile and sodium barbiturate to produce the corresponding amide, which is then reduced to obtain the target product.
Safety Information:
1-methyl -4-(3-pyrrolidinyl) piperazine dihydrochloride is neurotoxic and potentially dangerous to humans and the environment. When used in a laboratory or industrial environment, strict safety practices must be followed, and appropriate protective equipment must be worn to avoid contact with skin, inhalation or ingestion. Care should be taken to avoid the generation of dust when handling this compound and to operate in a well-ventilated environment. If you come into contact with this compound, wash the affected area immediately and seek medical help.
Last Update:2024-04-09 15:17:52