1-Piperidinecarboxylic acid, 4-acetyl-, 1,1-dimethylethyl ester
N-Boc-4-acetylpiperidine
CAS: 206989-61-9
Molecular Formula: C12H21NO3
1-Piperidinecarboxylic acid, 4-acetyl-, 1,1-dimethylethyl ester - Names and Identifiers
1-Piperidinecarboxylic acid, 4-acetyl-, 1,1-dimethylethyl ester - Physico-chemical Properties
| Molecular Formula | C12H21NO3 |
| Molar Mass | 227.3 |
| Density | 1.052±0.06 g/cm3(Predicted) |
| Boling Point | 312.4±35.0 °C(Predicted) |
| Flash Point | 142.714°C |
| Vapor Presure | 0.001mmHg at 25°C |
| pKa | -2.23±0.40(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.474 |
1-Piperidinecarboxylic acid, 4-acetyl-, 1,1-dimethylethyl ester - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | 25 - Toxic if swallowed |
| Safety Description | 45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1 / PGIII |
| Hazard Class | IRRITANT |
1-Piperidinecarboxylic acid, 4-acetyl-, 1,1-dimethylethyl ester - Introduction
N-Boc-4-acetylpiperidine is an organic compound with the chemical formula C11H17NO3.
Nature:
-Appearance: A colorless liquid
-Melting point:-3 ℃
-Boiling point: 268-270 ℃
-Density: 1.06g/cm³
-Solubility: Soluble in ethanol and ether, insoluble in water
Use:
- N-Boc-4-acetylpiperidine is an important organic synthesis intermediate, which has a wide range of applications in pharmaceutical synthesis, pesticide synthesis and other fields.
-It can be used to synthesize antibiotics, antiviral drugs, tumor treatment drugs and cardiovascular drugs.
Method:
N-Boc-4-acetylpiperidine are usually synthesized by the following steps:
1.4-acetyl piperidine dissolved in carbon tetrachloride;
2. Add cuprous chloride and tert-butyl alcohol, and then add copper hypochlorite as catalyst;
3. After the reaction is completed, acidify with acetic anhydride to generate N-Boc-4-acetylpiperidine.
Safety Information:
- N-Boc-4-acetylpiperidine is an organic compound that is irritating and photosensitive. In contact should pay attention to protective measures, avoid contact with skin and eyes.
-It should be kept in a cool, dry, well-ventilated place, away from fire and oxidants.
-Observe safe practices for chemicals during use and storage, and dispose of waste in accordance with local regulations.
Nature:
-Appearance: A colorless liquid
-Melting point:-3 ℃
-Boiling point: 268-270 ℃
-Density: 1.06g/cm³
-Solubility: Soluble in ethanol and ether, insoluble in water
Use:
- N-Boc-4-acetylpiperidine is an important organic synthesis intermediate, which has a wide range of applications in pharmaceutical synthesis, pesticide synthesis and other fields.
-It can be used to synthesize antibiotics, antiviral drugs, tumor treatment drugs and cardiovascular drugs.
Method:
N-Boc-4-acetylpiperidine are usually synthesized by the following steps:
1.4-acetyl piperidine dissolved in carbon tetrachloride;
2. Add cuprous chloride and tert-butyl alcohol, and then add copper hypochlorite as catalyst;
3. After the reaction is completed, acidify with acetic anhydride to generate N-Boc-4-acetylpiperidine.
Safety Information:
- N-Boc-4-acetylpiperidine is an organic compound that is irritating and photosensitive. In contact should pay attention to protective measures, avoid contact with skin and eyes.
-It should be kept in a cool, dry, well-ventilated place, away from fire and oxidants.
-Observe safe practices for chemicals during use and storage, and dispose of waste in accordance with local regulations.
Last Update：2024-04-09 02:00:44
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