1-acetyloxyethyl 2-(3-fluoro-4-phenyl-phenyl)propanoate
(±)-2-(2-Fluoro-4-biphenylyl)propionic acid 1-(acetoxy)ethyl ester
CAS: 91503-79-6
Molecular Formula: C19H19FO4
1-acetyloxyethyl 2-(3-fluoro-4-phenyl-phenyl)propanoate - Names and Identifiers
| Name | (±)-2-(2-Fluoro-4-biphenylyl)propionic acid 1-(acetoxy)ethyl ester |
| Synonyms | FP-83 Ropion ethyl ester Flurbiprofen axetil 1-acetoxyethyl 2-(2-fluorobiphenyl-4-yl)propanoate 1-acetyloxyethyl 2-(3-fluoro-4-phenylphenyl)propanoate 1-(acetyloxy)ethyl 2-(2-fluorobiphenyl-4-yl)propanoate 1-acetyloxyethyl 2-(3-fluoro-4-phenyl-phenyl)propanoate 1-Acetoxyethyl 2-(2-fluoro-[1,1'-biphenyl]-4-yl)propanoate (±)-2-(2-Fluoro-4-biphenylyl)propionic acid 1-(acetoxy)ethyl ester (±)-2-Fluoro-alpha-methyl-4-biphenylacetic acid 1-(acetoxy)ethyl ester 2-Fluoro-α-methyl(1,1'-biphenyl)-4-acetic acid 1-(acetyloxy)ethyl ester |
| CAS | 91503-79-6 |
| EINECS | 1308068-626-2 |
| InChI | InChI=1/C19H19FO4/c1-12(19(22)24-14(3)23-13(2)21)16-9-10-17(18(20)11-16)15-7-5-4-6-8-15/h4-12,14H,1-3H3 |
1-acetyloxyethyl 2-(3-fluoro-4-phenyl-phenyl)propanoate - Physico-chemical Properties
| Molecular Formula | C19H19FO4 |
| Molar Mass | 330.36 |
| Density | 1.169 |
| Boling Point | 174 °C(Press: 0.8 Torr) |
| Flash Point | 203°C |
| Water Solubility | Insoluble in water |
| Vapor Presure | 2.09E-07mmHg at 25°C |
| Appearance | clear liquid |
| Color | Colorless to Light yellow |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.528 |
| Physical and Chemical Properties | Colorless to yellowish transparent oily, slightly smelly and bitter. Miscible with methanol, ethanol, acetonitrile or acetone, insoluble in water. |
| Use | Content determination |
1-acetyloxyethyl 2-(3-fluoro-4-phenyl-phenyl)propanoate - Reference Information
| Non-steroidal analgesic agent | Flurbiprofen Axetil Injection is a non-steroidal analgesic agent using lipid microspheres as drug carriers. after the drug enters the body and distributes to the wound and tumor site, flurbiprofen axetil is released from the lipid microspheres, and rapidly hydrolyzed to produce flurbiprofen under the action of carboxy esterase, the analgesic effect is exerted by the inhibition of prostaglandin synthesis by flurbiprofen. flupiprofen is a non-steroidal anti-inflammatory drug that acts primarily by inhibiting Prostaglandin synthetase and has analgesic, anti-inflammatory and antipyretic effects. Its anti-inflammatory effect is 250 times that of acetylsalicylic acid, and its analgesic effect is 50 times that of acetylsalicylic acid. The effect is strong, fast, less adverse reaction. when the drug is used as an eye drop, it can inhibit miosis during cataract surgery and has no significant effect on intraocular pressure. The advantages of flurbiprofen axetil liposome preparation for injection are fast onset of action, long analgesic maintenance time, less toxic and side effects, and 3-10 times higher safety index than tablets. oral absorption is rapid, Tmax is 1.5h, tissue distribution is wide, PPB is 99.4%, and plasma protein can compete with high plasma protein binding drugs. Metabolized in the liver to hydroxyflurbiprofen and its uronic acid conjugates. T1/2 is 3.5 h. Excreted by urine and feces, about 60% and 40%, respectively. Age had no significant effect on drug metabolism. [indications] mainly for rheumatoid arthritis, rheumatoid arthritis, ankylosing spondylitis, degenerative arthritis. It can also prevent the occurrence of aphakic cystoid mottling edema after surgical removal of the lens, and inhibit the treatment of eye inflammation after surgery of pupillary contraction, cataract and trabeculectomy argon laser. |
| biological activity | Flurbiprofen Axetil is a commonly used anti-inflammatory drug that non-specifically inhibits cyclooxygenase COX. |
| Use | is a prodrug of flurbiprofen. It is used for pain relief after surgery and various cancers. |
| production method | flurbiprofen is dissolved in dimethylformamide, potassium carbonate and chloroethyl acetate are added, and the reaction is stirred at room temperature to obtain flurbiprofen ester. |
Last Update：2024-04-09 20:48:19
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View History
1-acetyloxyethyl 2-(3-fluoro-4-phenyl-phenyl)propanoate
603-15-6
AcetaMide, 2,2,2-trichloro-N-Methyl-
硬脂酸甘油脂
(1alpha,2beta,5alpha)-2-methyl-5-(1-methylethyl)bicyclo[3.1.0]hexan-2-ol
603-15-6
AcetaMide, 2,2,2-trichloro-N-Methyl-
硬脂酸甘油脂
(1alpha,2beta,5alpha)-2-methyl-5-(1-methylethyl)bicyclo[3.1.0]hexan-2-ol