Name | 2,3-Quinoline dicarboxylic acid |
Synonyms | Acridic acid 2,3-Quinoline dicarb 2,3-Quinolinedicarboxylic 1-acridinecarboxylic acid quinoline-2,3-dicarboxylicaci 2,3-QUINOLINE DICARBOXYLIC ACID QUINOLINE-2,3-DICARBOXYLIC ACID 2,3-Quinoline dicarboxylic acid Quinoline-2,3-dicarboxylic acid 2,3-Quinoline dicarboxylic acid (QDC) |
CAS | 643-38-9 |
InChI | InChI=1/C11H7NO4/c13-10(14)7-5-6-3-1-2-4-8(6)12-9(7)11(15)16/h1-5H,(H,13,14)(H,15,16) |
Molecular Formula | C11H7NO4 |
Molar Mass | 217.18 |
Density | 1.531±0.06 g/cm3(Predicted) |
Melting Point | 183 °C(Solv: benzene (71-43-2); ligroine (8032-32-4)) |
Boling Point | 423.7±40.0 °C(Predicted) |
Flash Point | 210°C |
Vapor Presure | 6.18E-08mmHg at 25°C |
pKa | 2.33±0.30(Predicted) |
Storage Condition | 2-8°C |
Refractive Index | 1.72 |
Physical and Chemical Properties | This product is crystalline material, Quinoline -2, 3-dicarboxylic acid Diethyl ester is brown liquid, pure m. P. 53 ℃, B. P. 230 ℃/2.27kPa. |
EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
Application | 2, 3-quinolinedicarboxylic acid can be used as intermediates in organic synthesis and pharmaceutical intermediates, mainly used in laboratory research and development process and chemical production process. |
Use | quinoline -2, 3-dicarboxylic acid is an intermediate of the herbicide imidazolinic acid. |
production method | the preparation method is based on the reaction of aniline and dimethyl butyneate as raw materials, the reaction product was subjected to a Vilsmeier reaction in the presence of phosphorus oxychloride and dimethylformamide to obtain methyl 2, 3-quinoline-dicarboxylate, which was then hydrolyzed in the presence of sulfuric acid to obtain a finished product. It is also possible to react aniline with diethyl 2, 3-dichlorobutanedioate to produce diethyl 2-anilino-fumarate, such as adding N,N-dimethylformamide in a toluene solvent and adding phosphorus oxychloride Dropwise at room temperature, after the addition, stirring was continued for 2h, and diethyl anilinobutenedioic acid was added dropwise. The reaction was heated and refluxed for 3 h, and the reaction was completed. The organic phase was washed with water, and toluene was distilled off to obtain diethyl quinoline -2, 3-dicarboxylate. |