1-cyclohexyl-1-phenyl-3-(1-piperidyl)propan-1-ol hydrochloride
benzhexol hydrochloride
CAS: 52-49-3
Molecular Formula: C20H31NO.ClH
1-cyclohexyl-1-phenyl-3-(1-piperidyl)propan-1-ol hydrochloride - Names and Identifiers
| Name | benzhexol hydrochloride |
| Synonyms | Trihexy Trihexane benzhexolchloride artanehydrochloride TRIHEXYPHENIDYL HCL Trihexyphenidyl HCL benzhexol hydrochloride TRIHEXYPHENIDYL HYDROCHLORIDE Trihexyphenidyl hydrochloride TRIHEXYLPHENIDYL HYDROCHLORIDE alpha-Cyclohexyl-alpha-phenyl-1-piperidinepropanol,HCl 1-Cyclohexyl-1-Phenyl-3-Piperidine Propanol Hydrochloride 1-phenyl-1-cyclohexyl-3-piperidyl-1-propanolhydrochloride 3-(1-piperidyl)-1-cyclohexyl-1-phenyl-1-propanolhydrochloride alpha-cyclohexyl-alpha-phenyl-1-piperidinepropanohydrochloride 1-cyclohexyl-1-phenyl-3-(1-piperidyl)propan-1-ol hydrochloride |
| CAS | 52-49-3 |
| EINECS | 200-142-5 |
| InChI | InChI=1/C20H31NO.2ClH/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21;;/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2;2*1H |
| InChIKey | QDWJJTJNXAKQKD-UHFFFAOYSA-N |
1-cyclohexyl-1-phenyl-3-(1-piperidyl)propan-1-ol hydrochloride - Physico-chemical Properties
| Molecular Formula | C20H31NO.ClH |
| Molar Mass | 337.93 |
| Density | 0.9801 (rough estimate) |
| Melting Point | Free base, mp 114.3-115.0° |
| Water Solubility | 670.9ug/L(22.5 ºC) |
| Solubility | H2O: soluble |
| Appearance | solid |
| Color | white |
| Merck | 14,9695 |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.5790 (estimate) |
| Use | For the treatment of elderly tremor disorder |
| In vivo study | In the first 3 months of the MWM test, the mean latency of Trihexyphenidyl(THP)-treated rats was significantly prolonged, and at 4-6 months, the behavioral deficit was repaired. Genes significantly down-regulated by THP are those associated with immune response, antigen processing and presentation, and major histocompatibility complex. In the aging brain, the treatment of THP reduces the expression of MHC class I. Long-term treatment of THP makes the hippocampus and cortical microglia in the motor area of rat frontal cortex change the inflammatory phenotype, structural changes. |
1-cyclohexyl-1-phenyl-3-(1-piperidyl)propan-1-ol hydrochloride - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | 36 - Wear suitable protective clothing. |
| UN IDs | 3249 |
| WGK Germany | 3 |
| RTECS | TN2625000 |
| HS Code | 2933399090 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | TDLo orl-wmn: 800 mg/kg:BAH BJPYAJ 145,300,84 |
1-cyclohexyl-1-phenyl-3-(1-piperidyl)propan-1-ol hydrochloride - Standard
Authoritative Data Verified Data
This product is (±)-a-cyclohexyl-a-phenyl -1-piperidine propanol hydrochloride. The content of C20H31NO • HC1 shall not be less than 98.0% calculated as dry product.
Last Update：2024-01-02 23:10:35
1-cyclohexyl-1-phenyl-3-(1-piperidyl)propan-1-ol hydrochloride - Trait
Authoritative Data Verified Data
- This product is white light crystalline powder; Odorless.
- This product is dissolved in methanol, ethanol or three gas methane, slightly soluble in water.
Last Update：2022-01-01 15:05:49
1-cyclohexyl-1-phenyl-3-(1-piperidyl)propan-1-ol hydrochloride - Differential diagnosis
Authoritative Data Verified Data
- take about 0.1g of this product and dissolve it with 5ml of ethanol at a slight temperature. After dropping the sodium hydroxide test solution into the litmus test paper, the precipitated precipitate will be recrystallized with ethanol and dried, the melting point measured according to law (General rule 0612) is 112 to 116°C.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 366).
- identification reaction of the product (General 0301).
Last Update：2022-01-01 15:05:49
1-cyclohexyl-1-phenyl-3-(1-piperidyl)propan-1-ol hydrochloride - Exam
Authoritative Data Verified Data
optical rotation
take this product, precision weighing, add methanol-dichloromethane (20:80) dissolved and quantitatively diluted into solution containing 50mg per lml, determination according to law (General 0621), the optical rotation is from 0.10 ° to +0.10 °.
chlorine content
take this product about 0.6g, precision weighing, add methanol 50ml, glacial acetic acid 5ml and water 5ml dissolved, add eosin sodium indicator solution 3 drops, with silver nitrate titration solution (0.1 mol/L) titrated to rapidly turn red and produce a red suspension. Each 1 ml of silver nitrate titration solution (0.1 mol/L) corresponds to 3.545mg of C1. The chlorine content shall be 10.3%-10.7% based on the dry product.
acidity
take 0.50g of this product, add 50ml of water, heat to about 80°C, shake to dissolve, cool, and determine according to law (General rule 0631),pH value should be 5.0~6.0.
piperidine phenylacetone
take 0.10g of this product, add water 40ml, and hydrochloric acid solution (9-100) 1 ml, heat to dissolve, cool, add water to 100ml, shake, according to UV-visible spectrophotometry (General rule 0401), measured at the wavelength of 247nm, the absorbance should not be greater than 0.50.
Related substances
take this product, add mobile phase to dissolve and dilute to make a solution containing about 1 mg per 1ml as a test solution; Take 1ml for precision measurement and put it in a 200ml measuring flask, dilute to the scale with the mobile phase, shake, and serve as a control solution. According to the test of high performance liquid chromatography (General 0512), silica gel was bonded with eighteen alkyl silane as filler; 0.1% triethylamine solution (adjusted to pH 4.0 with phosphoric acid)-acetonitrile (70:30) it is the mobile phase, the detection wavelength is 210nm, and the number of theoretical plates is not less than 2000 according to the calculation of the peak of the benzene. 20 ml of the test solution and the control solution were respectively injected into the liquid chromatograph, and the chromatogram was recorded to 3 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than the area of the main peak of the control solution (0.5%), the sum of each impurity peak area shall not be greater than 2 times (1.0%) of the main peak area of the control solution.
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).
ignition residue
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
Heavy metals
The residue left under the item of burning and flooding shall not contain more than 20 parts per million of heavy metals for examination by law (General rule 0821, Law II).
Last Update：2022-01-01 15:05:50
1-cyclohexyl-1-phenyl-3-(1-piperidyl)propan-1-ol hydrochloride - Content determination
Authoritative Data Verified Data
take this product about 0.3g, precision weighing, add anhydrous formic acid 10ml and acetic anhydride 40ml dissolved, according to the potential titration method (General rule 0701), with perchloric acid titration solution (O. 1 mol/L) titration, and the results of the titration were corrected with a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 33.79mg of c20 h31no. Hc1.
Last Update：2022-01-01 15:05:51
1-cyclohexyl-1-phenyl-3-(1-piperidyl)propan-1-ol hydrochloride - Category
Authoritative Data Verified Data
Anti-Parkinson's disease drugs.
Last Update：2022-01-01 15:05:51
1-cyclohexyl-1-phenyl-3-(1-piperidyl)propan-1-ol hydrochloride - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 15:05:51
1-cyclohexyl-1-phenyl-3-(1-piperidyl)propan-1-ol hydrochloride - Benzhexol Hydrochloride Tablets
Authoritative Data Verified Data
This product contains benzhexol hydrochloride (C20H31NO • HCI) should be labeled the amount of 93.0% ~ 107.0%.
trait
This product is white tablet.
identification
- take an appropriate amount of fine powder of this product (about 20mg of benzhexol hydrochloride), add 20ml of water, shake to dissolve benzhexol hydrochloride, filter, and the filtrate is divided into two parts: add trinitrophenol test solution in one part, that is, a yellow precipitate is formed; A white precipitate is formed by adding 20% sodium hydroxide solution to the other portion.
- take an appropriate amount of the fine powder of this product, add chloroform to dissolve and dilute the benzhexol hydrochloride into a solution containing about 2mg per 1 ml, filter and use it as a test solution, chloroform was added to dissolve and diluted to prepare a solution containing about 2mg per 1 ml as a control solution. According to the thin layer chromatography (General 0502) test, absorb 10 u1 of each of the above two solutions, respectively point on the same silica gel G thin layer plate, with chloroform-methanol (9:1) as the developing solvent, it was developed, dried, and sprayed with dilute bismuth potassium iodide solution for color development. The position and color of the main spot displayed by the test solution should be the same as that of the reference solution.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- items (2) and (3) above are optional.
examination
- relevant substances: take an appropriate amount of the fine powder of this product, and add the mobile phase to shake to dissolve and dilute the benzhexol hydrochloride to prepare a solution containing about 1 mg per 1 ml as the test solution; determination of related substances of benzhexol hydrochloride by this method. If there are impurity peaks in the chromatogram of the test solution, the peak before the relative retention time of about 0.2 shall be excluded, and the area of a single impurity peak shall not be greater than the area of the main peak of the control solution (0.5% ) , the sum of each impurity peak area shall not be greater than 2 times (1.0%) of the main peak area of the control solution.
- Content uniformity take 1 tablet of this product, put it in 25ml measuring flask, add appropriate amount of mobile phase, ultrasonic dissolve benzhexol hydrochloride, let it cool, dilute it to the scale with mobile phase, shake well, filter, the content of the continued filtrate shall be determined according to the method under the content determination item, and shall comply with the regulations (General rule 0941).
- the dissolution of this product, according to the dissolution and release determination method (General rule 0931 The first method), with water as the dissolution medium, the speed is 100 rpm, according to the law, after 30 minutes, take about 10ml solution, filter, according to the chromatographic conditions under the content determination item, take the precise amount of filtrate 50u1 and inject it into the liquid chromatograph, record the chromatogram; Take the reference substance of benzhexol hydrochloride, precision weighing, dissolved and quantitatively diluted with water to make a solution containing about 4ug per lml, determined by the same method, and the dissolution amount of each tablet was calculated by peak area according to external standard method. The limit is 75% of the labeled amount and shall be in accordance with the provisions.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
- measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as filler; With 0.1% triethylamine solution (adjusted to pH 4.0 with phosphoric acid)-acetonitrile (70:30) as mobile phase; the detection wavelength was 210nm. The number of theoretical plates shall not be less than 2000 based on the peak of benzhexol.
- determination of 20 tablets of this product, precision weighing, fine, precision weighing an appropriate amount (equivalent to 4mg of benzhexol hydrochloride), put in a 50ml measuring flask, add an appropriate amount of mobile phase, ultrasonic dissolution of benzhexol hydrochloride, cool, dilute to the scale with mobile phase, shake, filter, take the filtrate as the test solution, take 10u1 injection of human liquid chromatography with precision, record the chromatogram; Take the reference substance of benzhexol hydrochloride, precision weighing, plus mobile phase dissolution and quantitative dilution of the solution containing about 80ug per 1 ml, the same method for determination. According to the external standard method to calculate the peak area, that is.
category
with benzhexol hydrochloride.
specification
2mg
storage
sealed storage.
Last Update：2022-01-01 15:05:52
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Product Name: benzhexol hydrochloride Request for quotation
CAS: 52-49-3
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
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Product List: View Catalog
CAS: 52-49-3
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
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Product List: View Catalog
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Product Name: Trihexyphenidyl hydrochloride Visit Supplier Webpage Request for quotationCAS: 52-49-3
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