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1-hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridon monoethanolamine salt

Piroctone Oleamine

CAS: 68890-66-4

Molecular Formula: C16H30N2O3

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1-hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridon monoethanolamine salt - Names and Identifiers

Name Piroctone Oleamine
Synonyms Octopirox
octopiroxolamine
piroctone olamine
Piroctone Oleamine
Pyridine-amino ethanol
Hydroxyl pyrazole ketones
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)
1-Hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridon monoethanolamine
4,4-trimethylpentyl)-1-hydroxy-4-methyl-6-(compd.with2-2(1h)-pyridinon
1-hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridon monoethanolamine salt
CAS 68890-66-4
EINECS 272-574-2
InChI InChI=1/C14H23NO2.C2H7NO/c1-10-6-12(15(17)13(16)8-10)7-11(2)9-14(3,4)5;3-1-2-4/h6,8,11,17H,7,9H2,1-5H3;4H,1-3H2
InChIKey BTSZTGGZJQFALU-UHFFFAOYSA-N

1-hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridon monoethanolamine salt - Physico-chemical Properties

Molecular FormulaC16H30N2O3
Molar Mass298.43
Density1.1[at 20℃]
Melting Point134.0 to 138.0 °C
Boling Point135-235℃[at 101 325 Pa]
Flash Point161.9°C
Water Solubility400-50000mg/L at 20-25℃
Solubility Chloroform (Slightly, Sonicated), Methanol (Slightly)
Vapor Presure0-0Pa at 20-25℃
Appearanceneat
ColorWhite to Off-White
Merck14,7502
pKa5.9-7.4[at 20 ℃]
Storage ConditionInert atmosphere,2-8°C
MDLMFCD01690792
In vitro study Piroctone olamine, the ethanolamine salt of the hydroxamic acid derivative Piroctone, is a hydroxypyridone anti-mycotic agent. Piroctone olamine penetrates the cell membrane and forms complexes with iron ions, inhibiting energy metabolism in mitochondria. Piroctone olamine (PO) is an ethanolamine salt of the hydroxamic acid derivative Piroctone. All Candida strains show low minimum inhibitory concentrations (MICs) for Piroctone olamine (0.125-0.5 μg/mL) and Amphotericin B (AMB) (0.03-1 μg/mL).
In vivo study This work aimed to evaluate the antifungal activity of Piroctone olamine in the treatment of intra-abdominal candidiasis in an experimental model using Swiss mice. The treatment with Piroctone olamine (0.5 mg/kg) is performed 72 h after infection by intraperitoneal administration. For comparison, a group of animals (n=6) is treated with Amphotericin B (0.5 mg/kg). The mycological diagnosis is made by collecting the liver, spleen and kidneys. Data regarding the fungal growth and mortality are analyzed statistically by Student’s t test and analysis of variance, with level of significance set at P<0.05. The difference in fungal growth scoring between the control group and the treatment groups (Piroctone olamine and Amphotericin B) is statistically significant (P<0.05).

1-hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridon monoethanolamine salt - Risk and Safety

WGK Germany2
RTECSUU7786150
HS Code2933399090

1-hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridon monoethanolamine salt - Reference Information

LogP1.05-3.86 at 20-25℃
Introduction the unique properties of pirrocone ethanolamine salt are mainly manifested in: 1. The anti-dandruff and anti-itching effect is better than that of similar products. 2. The dissolution performance and compounding performance are excellent, and the precipitation or stratification phenomenon will not occur when mixed with the raw materials of cosmetics. 3. Unique anti-dandruff mechanism, very low irritation, will not cause hair loss, hair loss, safety is better than similar anti-dandruff and anti-itching products.
Use oxycodone is an efficient, non-toxic and non-irritating anti-dandruff agent, which can be widely used in anti-dandruff shampoo, hair liquid and hair conditioner and other care cosmetics.
biological activity Piroctone olamin is a pyridine derivative. Has a fungicidal effect.
Target specific
Last Update：2024-04-09 21:21:28
1-hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridon monoethanolamine salt
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Jiangsu Pules Biotechnology Co.,Ltd.
Product Name: Piroctone Oleamine Request for quotation
CAS: 68890-66-4
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
JIANGSU BSECHEM CHEMICAL TECHNOLOGY CO., LTD.
Spot supply
Product Name: Piroctone Oleamine Request for quotation
CAS: 68890-66-4
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3787852685 Click to send a QQ messageSend QQ message
Nantong Reform Petro-Chemical CO., LTD.
Spot supply
Product Name: Piroctone Oleamine Request for quotation
CAS: 68890-66-4
Tel: +86-17551318830
Email: r@reformchem.com­
Mobile: +86-17551318830
QQ: 3785839865 Click to send a QQ messageSend QQ message
Guangzhou Yuanda New Material Co.,Ltd
Product Name: Piroctone olamine Request for quotation
CAS: 68890-66-4
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589 Click to send a QQ message
Wechat: +86 19849939632
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Piroctone Oleamine Request for quotation
CAS: 68890-66-4
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Wuhan Xingzhongcheng Chemical limited company
Spot supply
Product Name: Piroctone Oleamine Request for quotation
CAS: 68890-66-4
Tel: 86+027-83389957
Email: 1024042217@qq.com
Mobile: 86+18627766980
QQ: 1024042217 Click to send a QQ message
Wechat: 18627766980
Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple SpecificationsSpot supply
Product Name: Piroctone olamine Visit Supplier Webpage Request for quotation
CAS: 68890-66-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Shanghai Worldyang Chemical Co.,Ltd.
Product Name: Piroctone olamine Request for quotation
CAS: 68890-66-4
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228 Click to send a QQ message
Wechat: 13651600618
WhatsApp: +8613651600618
Zouping Mingxing Chemical Co., Ltd.
Product Name: Piroctone Olamine Request for quotation
CAS: 68890-66-4
Tel: 0086-13605431940
Email: xuli678323@126.com
Mobile: +86-13605431940
QQ: 56860987 Click to send a QQ message
Wechat: 13605431940
WhatsApp: 13605431940
Bisor Corporation
Product Name: Piroctone Olamine Request for quotation
CAS: 68890-66-4
Tel: 021-61834121
Email: kim@bisorcare.com
Mobile: 13262698927
QQ: 3035159560 Click to send a QQ messageSend QQ message
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1-hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridon monoethanolamine salt
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