1-溴-4-氟萘
1-Bromo-4-fluoronaphthalene
CAS: 341-41-3
Molecular Formula: C10H6BrF
1-溴-4-氟萘 - Names and Identifiers
| Name | 1-Bromo-4-fluoronaphthalene |
| Synonyms | BUTTPARK 44 9-75 1-Bromo-4-fluonaphthalene 1-fluoro-4-bromonaphthalene 1-FLUORO-4-BROMONAPHTHALENE 1-BROMO-4-FLUORONAPHTHALENE 1-Bromo-4-fluoronaphthalene Naphthalene, 1-bromo-4-fluoro- |
| CAS | 341-41-3 |
| EINECS | 206-434-9 |
| InChI | InChI=1/C10H6BrF/c11-9-5-6-10(12)8-4-2-1-3-7(8)9/h1-6H |
1-溴-4-氟萘 - Physico-chemical Properties
| Molecular Formula | C10H6BrF |
| Molar Mass | 225.06 |
| Density | 1.563±0.06 g/cm3(Predicted) |
| Melting Point | 35-38 °C (lit.) |
| Boling Point | 110-115 °C(Press: 2 Torr) |
| Flash Point | >230°F |
| Solubility | Chloroform (Slightly), DMSO (Slightly) |
| Vapor Presure | 0.00609mmHg at 25°C |
| Appearance | Solid |
| Color | White Low-Melting |
| BRN | 2085804 |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.638 |
| MDL | MFCD00051473 |
1-溴-4-氟萘 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 29039990 |
| Hazard Class | IRRITANT |
1-溴-4-氟萘 - Reference Information
| introduction | 1-bromo-4-fluoronaphthalene is an organic intermediate, which can be obtained from 1-fluoronaphthalene bromine. 1-Bromo-4-fluoronaphthalene can be used to prepare 4-fluoronaphthalene-1-ol. The hydroxyl group in the structure of 4-fluoronaphthalene-1-ol has greater activity and can react with many functional groups. The ortho-para positioning effect of the hydroxyl group activates the naphthalene ring and can introduce other functional groups in the ortho-position of the hydroxyl group. It is an important pharmaceutical and chemical intermediate. |
| application | 1-bromo-4-fluoronaphthalene can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development process and chemical production process. |
| preparation | in a 500mL single-mouth bottle, 1-fluoronaphthalene (20.0g,0.137mol) and carbon tetrachloride (120.0mL) were added, bromine (10.9g,0.068mol) was added dropwise, and refluxed for 2 hours. After the reaction is completed, the concentrated solution is concentrated under reduced pressure, and the concentrated solution is poured into methanol (80.0mL) and left to stand at low temperature overnight to precipitate the solid, and the 1-bromo -4-fluoronaphthalene 28.0g is obtained by suction filtration. |
Last Update：2024-04-09 21:01:54
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