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100929-47-3

Doxycycline HCl

CAS: 10592-13-9;100929-47-3

Molecular Formula: C22H25ClN2O8

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  5. 100929-47-3

100929-47-3 - Names and Identifiers

Name Doxycycline HCl
Synonyms DOXYCYCLINE HCL
VIBRAMYCIN, HCL
Doxycycline HCl
DOXYCYCLINE HYDROCHLORIDE
Doxycycline Hydrochloride
DOXYCYCLINI HYDROCHLORIDUM
ALPHA-6-DEOXY-5-HYDROXYTETRACYCLINE
Doxycycline Hydrochloride Anhydrous
4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
2-(AMINO-HYDROXY-METHYLIDENE)-4-DIMETHYLAMINO-5,10,11,12A-TETRAHYDROXY-6-METHYL-4A,5,5A,6-TETRAHYDRO-4H-TETRACENE-1,3,12-TRIONE
(4s,4ar,5s,5ar,6r,12as)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide hydrochloride
(2Z,4S,4aR,5S,5aR,6R)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5a,6,12a-tetrahydrotetracene-1,3,12(2H,4H,5H)-trione hydrochloride
(1S,3Z,4aS,11R,11aR,12S,12aR)-3-[amino(hydroxy)methylidene]-4a,6,7,12-tetrahydroxy-N,N,11-trimethyl-2,4,5-trioxo-1,2,3,4,4a,5,11,11a,12,12a-decahydrotetracen-1-aminium chloride
CAS 10592-13-9
100929-47-3
EINECS 234-198-7
InChI InChI=1/C22H24N2O8.ClH/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);1H/t7-,10+,14+,15-,17-,22-;/m0./s1

100929-47-3 - Physico-chemical Properties

Molecular FormulaC22H25ClN2O8
Molar Mass480.9
Melting Point206-209°C
Boling Point685.2°C at 760 mmHg
Specific Rotation(α)D25 -110° (c = 1 in 0.01N methanolic HCl)
Solubility water: 50 mg/mL
Appearancecrystalline solid(yellow to yellow-green)
Storage Condition2-8℃
MDLMFCD07357237
UseAntibiotics for infections caused by gram-positive cocci and gram-negative bacilli

100929-47-3 - Upstream Downstream Industry

Raw MaterialsQuinaldine
N-Acetylaniline
Starch potato
Dextrose Anhydrate
Oxytetracycline
Ethyl Alcohol

100929-47-3 - Reference

Reference
Show more
1. Liang Jinling, Huang Yuxia, He Jinxing. Determination of Tetracycline Antibiotic Residues in Chicken by Molecularly Imprinted Solid Phase Extraction-High Performance Liquid Chromatography [J]. 2018 of Modern Food Science and Technology v.34;No.227(07):224-229.
2. Zhang Jipei, Wei Qinglan, Tan Hualong, et al. Drug resistance and drug resistance gene detection of waterfowl Escherichia coli to tetracycline in Guangdong [J]. Animal Husbandry and Veterinary Medicine, 2015, 47(012):94-97.
3. Ma Zhenzhen, Zhao Tao, he Jinxing. Preparation of Tetracycline Molecularly Imprinted-Biochar Composites by Pickering Emulsion Polymerization [C]// Abstracts of the 15th Annual Meeting of China Food Science and Technology Society. 2018.
4. Cen Daoji, Mai Jialin, Zhou Yuyuan, et al. Drug Resistance Status of Escherichia coli in Guangdong Goose Farm and Transmission Characteristics of blaCTX-M Genes [J]. China Animal Husbandry and Veterinary Medicine, 202,047 (005):1571-1582.

100929-47-3 - Standard

Authoritative Data Verified Data

This product is 6-methyl -4-(dimethylamino)-3,5,10,12, 12a-pentahydroxy-1, 11-dioxo-1, 4,4a,5,5a,6,11, 12a-octahydro -2-tetrabenzamide hydrochloride hemiethanol hemihydrate. Doxycycline-containing (C22H24N208) should be between 88.0% and 94.0% based on anhydrous and ethanol-free material.

Last Update：2024-01-02 23:10:35

100929-47-3 - Trait

Authoritative Data Verified Data
  • This product is light yellow to yellow crystalline powder; Odorless.
  • This product is soluble in water or methanol, and slightly soluble in ethanol or acetone.

specific rotation

take this product, precision weighing, add hydrochloric acid solution (9-100) of methanol solution (1-100) dissolved and quantitatively diluted to make a solution containing about 10 mg per 1 ml, at 25°C, determination according to law (General rule 0621), calculated as anhydrous and alcohol-free, the specific rotation is 105 ° to -120 °.

Last Update：2022-01-01 14:23:18

100929-47-3 - Differential diagnosis

Authoritative Data Verified Data
  1. in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
  2. take an appropriate amount of this product, add methanol to dissolve and dilute to make a solution containing 20ug per lml, and measure by UV-Vis spectrophotometry (General rule 0401), there is maximum absorption at wavelengths of 269nm and 354nm, and minimum absorption at wavelengths of 234nm and 296Nm.
  3. The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 386).
  4. the aqueous solution of this product was chloride identification (1) of the reaction (General 0301).
Last Update：2022-01-01 14:23:18

100929-47-3 - Exam

Authoritative Data Verified Data

acidity

take this product, add water to make a solution containing lOmg per lml, and determine it according to law (General 0631). The pH value should be 2.0~3.0.

Related substances

take this product, add O.Olmol/L hydrochloric acid solution is dissolved and diluted to make a solution containing about 0.2mg of doxycycline per 1 ml, as a test solution; Take an appropriate amount of precision, use O. A solution containing about 1 ml of doxycycline was prepared by quantitative dilution of 1 mol/L hydrochloric acid solution as a control solution. According to the chromatographic conditions under the content determination item, 20 u1 of the test solution and the control solution are accurately measured, and the human liquid chromatograph is injected respectively, and the chromatogram is recorded to 2 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the peak areas of Ritalin and B- doxycycline shall not be greater than the main peak area of the control solution (2.0% ) , other single impurity peak area shall not be greater than 0.5 times (1.0%) of the main peak area of the control solution, and the sum of each impurity peak area shall not be greater than 2 times (4.0%) of the main peak area of the control solution.

absorbance of impurities

take this product, precision weighing, add hydrochloric acid solution (9-100) of methanol solution (1-100) dissolved and quantitatively diluted into each lml solution containing lOmg, UV-visible spectrophotometry (General rule 0401), measured at a wavelength of 490nm, the absorbance should not exceed 0.12.

ethanol

take this product about l. Add internal standard solution (0.5% N-propanol solution) to a 10ml measuring flask for dissolution and dilution to the scale; precise weighing anhydrous ethanol about 0.5g, put it in a measuring flask, add the above internal standard solution to dilute to the scale, shake, as a reference solution. According to the gas chromatography method (General 0521), a porous polymer pellet of divinyl-ethylvinylbenzene type was used as the stationary phase, and the column temperature was 135 ° C.; The inlet temperature and the detector temperature were both 150 ° C. Fig. The resolution between ethanol peak and N-propanol peak should meet the requirements. The sample solution and the reference solution are respectively injected with human gas chromatograph, and the chromatogram is recorded. The ratio of peak area is calculated according to the internal standard method, and the amount of ethanol should be 4.3% ~ 6.0%.

moisture

take this product, according to the moisture determination method (General 0832 first method 1), the moisture content should be 1.5% ~ 3.0%.

ignition residue

lg of this product shall be taken for inspection according to law (General rule 0841), and the remaining residue shall not exceed 0.2%.

Heavy metals

The residue left under the item of taking the ignition residue shall not contain more than 20 parts per million of heavy metal when examined by law (General rule 0821, Law II).

Last Update：2022-01-01 14:23:19

100929-47-3 - Content determination

Authoritative Data Verified Data

measured by high performance liquid chromatography (General 0512).

chromatographic conditions and system suitability test

silica gel bonded with octylsilane as filler (pH range should be greater than 9 ) ; Acetate buffer [0.25mol/L ammonium acetate -0.1 mol/L ethylenediamine tetraacetic acid disodium triethylamine (100:10:1), using glacial acetic acid or ammonia to adjust pH to 8.8]-acetonitrile (85:15) as mobile phase; the column temperature was 35°C; The detection wavelength was 280mn. Add O.Olmol/L hydrochloric acid solution was dissolved and diluted to prepare about oxytetracycline, dextromethorphan and B- doxycycline in 1 ml. 1 mg and doxycycline 0.2mg mixed solution, 20u1 injection human liquid chromatograph, record chromatogram, doxycycline peak and doxycycline peak separation degree should be greater than 4.0, the resolution between doxycycline peak and impurity F peak should meet the requirements.

assay

take the right amount of this product, precision weighing, plus O.Olmol/L hydrochloric acid solution was dissolved and quantitatively diluted to make doxycycline in each 1 ml. 1 mg solution, as the test solution, the precision of 20ul injection into the liquid chromatograph, record the chromatogram; Another appropriate amount of doxycycline control, the same method for determination. The content of C22H24N208 in the test sample was calculated by the peak area according to the external standard method.

Last Update：2022-01-01 14:23:20

100929-47-3 - Category

Authoritative Data Verified Data

Tetracycline antibiotics.

Last Update：2022-01-01 14:23:20

100929-47-3 - Storage

Authoritative Data Verified Data

light shielding, sealed storage.

Last Update：2022-01-01 15:03:41

100929-47-3 - DoxycyclineHyclateTablets

Authoritative Data Verified Data

This product contains doxycycline hydrochloride according to doxycycline (C22H24N2O8) calculation, should be the standard amount of 93.0% ~ 107.0%.

trait

This product is a light yellow tablet or film-coated tablet, which shows a light yellow color after removing the coating.

identification

  1. in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
  2. take an appropriate amount of the fine powder of this product, add methanol to dissolve and dilute to make a solution containing 20ug doxycycline per lml, filter, take the filtrate, according to UV-visible spectrophotometry (General 0401) it was determined that there was a maximum absorption at the wavelengths of 269nm and 354nm and a minimum absorption at the wavelengths of 234nm and 296Nm.

examination

  • Related Substances: take an appropriate amount of the fine powder of this product, dissolve and dilute it with 0.01mol/L hydrochloric acid solution to make a solution containing about 0.2mg doxycycline per 1 ml, filter it, the continued filtrate was taken as the test solution, and the peak areas of doxycycline hydrochloride and B- doxycycline were not greater than the main peak area of the control solution (2.0%) according to the method under doxycycline hydrochloride, other single impurity peak area shall not be greater than 0.5 times (1.0%) of the main peak area of the control solution, and the sum of each impurity peak area shall not be greater than 2.5 times (5.0%) of the main peak area of the control solution.
  • absorbance of impurities 5 tablets of this product were finely divided, dissolved and quantitatively diluted with methanol solution (1-100) of hydrochloric acid solution (9-100) to prepare a solution containing about 9mg of doxycycline per 1 ml, and filtered, take the filtrate, according to UV-visible spectrophotometry (General 0401), measured at the wavelength of 490mn, absorbance should not exceed 0.20.
  • the dissolution of this product, according to the dissolution and release determination method (General rule 0931 second method), water 900ml as the dissolution medium, the speed of 50 rpm, according to the law, 45 minutes, take the appropriate amount of solution, filtration, precision take the appropriate amount of filtrate, quantitative dilution of water to make a solution containing 20ug of doxycycline per 1 ml, according to UV-visible spectrophotometry (General rule 0401), determine absorbance at the wavelength of 276mn, and take appropriate amount of doxycycline reference substance, water was added to dissolve and quantitatively diluted to prepare a solution containing about 20ug per 1 ml, which was determined by the same method, and the dissolution amount of each tablet was calculated. The limit is 85% of the labeled amount and shall be in accordance with the provisions.
  • others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).

Content determination

Take 10 tablets of this product, precise weighing, fine grinding, precise weighing appropriate amount (about 0.1g equivalent to doxycycline), put it in a 100ml measuring flask, add 0.01mol/L hydrochloric acid solution to dissolve and dilute to the scale, shake well, filter, accurately take 5ml of continued filtrate, put it in a 50ml measuring flask, diluted with 0.01mol/L hydrochloric acid solution to the scale, shake, as a test solution, according to the method under the item doxycycline hydrochloride, obtained.

category

Same as doxycycline hydrochloride.

specification

Based on C22H24N208 (1)0.05g (2) 0.1g

storage

light shielding, sealed storage.

Last Update：2022-01-01 15:03:42

100929-47-3 - Doxycycline Hyclate Capsules

Authoritative Data Verified Data

This product contains doxycycline hydrochloride according to doxycycline (C22H24N2O8) calculation, should be 90.0% ~ 110.0% of the label amount.

trait

The content of this product is light yellow to yellow powder or granules.

identification

  1. in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
  2. take an appropriate amount of the contents of this product, add methanol to dissolve and dilute to make a solution containing 20ug doxycycline per lml, filter, take the filtrate, according to UV-visible spectrophotometry (General 0401) it was determined that there was a maximum absorption at the wavelengths of 269nm and 354nm and a minimum absorption at the wavelengths of 234nm and 296Nm.

examination

  • appropriate amount of contents under the item of difference in loading of related substances, precision weighing, add 0.Olmol/L hydrochloric acid solution is dissolved and diluted to make a solution containing about 0.2mg of doxycycline per 1 ml, filtered, and the continued filtrate is taken as the test solution, which is determined according to the method under doxycycline hydrochloride, both the peak areas of ritacycline and B- doxycycline shall not be greater than the main peak area of the control solution (2.0% ) , and the peak areas of other individual impurities shall not be greater than 0.5 times (1.0%) of the main peak area of the control solution, the Peak area of each impurity shall not be greater than 2.5 times (5.0%) of the main peak area of the control solution.
  • loss on drying: take an appropriate amount of the contents of this product, dry to constant weight at 105°C, and lose no more than 8.5% of the weight (General rule 0831).
  • the dissolution of this product, according to the dissolution and release determination method (General rule 0931 second method), water 900ml as the dissolution medium, the speed of 50 rpm, according to the law, after 45 minutes, take the appropriate amount of solution, filter, take the appropriate amount of filtrate, dilute quantitatively with water to make a solution containing 20ug of doxycycline per 1 ml, according to UV-visible spectrophotometry (General rule 0401), the absorbance was measured at the wavelength of 276nm, water was added to dissolve and quantitatively diluted to prepare a solution containing about 20ug per 1 ml, which was determined by the same method, and the dissolution amount of each particle was calculated. The limit is 85% of the labeled amount and shall be in accordance with the provisions.
  • others should comply with the relevant provisions under the capsule (General 0103).

Content determination

take the contents under the item of loading difference, mix evenly, accurately weigh the appropriate amount (about equivalent to doxycycline O.lg), put in a 100ml measuring flask, add O.Olmol/L hydrochloric acid solution dissolved and diluted to the scale, shake, filter, precision take the filtrate 5ml, put 50ml flask, add 0.Olmol/L hydrochloric acid solution diluted to the scale, shake, as a test solution, according to the method of doxycycline hydrochloride under the item, obtained.

category

Same as doxycycline hydrochloride.

specification

0.lg (based on C22H24N2O8)

storage

sealed and stored in a cool and dry place.

Last Update：2022-01-01 15:03:43

100929-47-3 - Introduction

Doxycycline HCl is a broad spectrum antibiotic that is widely used to treat a variety of infectious conditions. It can be used to treat infections of the respiratory tract, skin, genitourinary system, digestive tract, eyes, and other sites. It can effectively inhibit the growth and reproduction of bacteria, so as to play a role in sterilization.

Doxycycline HCl can be prepared by reacting doxycycline with hydrochloric acid. Doxycycline is a yellow-like pigment with a tetracyclic structure that reacts with hydrochloric acid to form Doxycycline HCl, which is soluble in water.

Safety attention is required when using Doxycycline HCl. It may cause some common side effects, such as nausea, vomiting, diarrhea, headache, loss of appetite, etc. In the course of use should follow the doctor's advice, pay attention to the dosage and use time. And pay attention to the use of restrictions in pregnant women, lactating women, children and other specific groups.

In addition, Doxycycline HCl may also cause color changes to the teeth, it is necessary to strengthen oral hygiene during use and try to avoid using it in children during tooth development.
Last Update：2024-04-09 20:52:54
100929-47-3
Supplier List
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Doxycycline HCl Request for quotation
CAS: 10592-13-9
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
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Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple SpecificationsSpot supply
Product Name: Doxycycline Hydrochloride Visit Supplier Webpage Request for quotation
CAS: 10592-13-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Doxycycline HCl Request for quotation
CAS: 10592-13-9
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple SpecificationsSpot supply
Product Name: Doxycycline Hydrochloride Visit Supplier Webpage Request for quotation
CAS: 10592-13-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
View History
100929-47-3
Raw Materials for 100929-47-3
Quinaldine
N-Acetylaniline
Starch potato
Dextrose Anhydrate
Oxytetracycline
Ethyl Alcohol
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